摘要
目的对药物超敏综合征(drug induced hypersensitivity syndrome,DIHS)患者临床症状消失、巨细胞病毒抗体转阴后进行可疑致敏药物的皮肤斑贴试验与口服激发试验,为了解病毒感染在DIHS中的发病机制提供依据。方法 1例可疑致敏药物为美西律和头孢呋辛的DIHS患者临床痊愈2年后行皮肤斑贴试验,分别于48、72和120 h连续观察,均未出现皮疹为阴性;另外,行口服激发试验,服药期间和停药1周内未出现发疹和发热为阴性。结果斑贴试验阴性,口服激发试验后随访20个月未有发热、发疹。结论 DIHS是由病毒感染参与、T淋巴细胞介导的迟发型超敏反应,病毒感染是导致该型药疹发生的"共因子"。
The patch test and oral irritating test of suspected allergic drugs were investigated in a patient with drug rash with eosinophitia and systemic symptoms （DRESS）also known as drug induced hypersensitivity syndrome （DIHS ） after clinical recovery and CMV IgG showing negative so that the mechanism of DRESS could be known much.Methods Patch tests were made with suspected allergic drugs mexiletine and cefuroxime.The results were observed after 48,72 and 1 20 hours continuously.Oral irritating tests were made after the negative result of patch test.Results Patch tests of the both suspected allergic drugs were negative,and the oral irritating tests were also negative because the patient were neither fever nor eruption 20 months later.Conclusions DRESS is a delayed hypersensitivity reaction mediated by T lymphocyte,in which virus infection is the cofactor of its onset.
出处
《中华临床免疫和变态反应杂志》
2014年第2期134-137,共4页
Chinese Journal of Allergy & Clinical Immunology
关键词
药物超敏综合征
巨细胞病毒
斑贴实验
激发实验
drug induced hypersensitivity syndrome
cytomegalovirus
skin patch test
oral irritating test
