摘要
目的:探讨成人斯蒂尔病(AOSD)患者血清中巨噬细胞移动抑制因子(MIF)、白细胞介素-6(IL-6)的表达水平对AOSD病情的影响。方法:采用酶联免疫吸附试验(ELISA)测定32例病情活动期AOSD患者、26例病情稳定期AOSD患者及20例健康志愿者血清中MIF、IL-6水平。结果:活动期AOSD患者血清中MIF、IL-6水平显著高于稳定期AOSD及健康对照(P<0.05),活动期AOSD患者MIF与白细胞计数(WBC)呈正相关,而与IL-6、红细胞沉降率(ESR)、C反应蛋白(CRP)、血小板计数(PLT)、铁蛋白(SF)间无相关性,活动期AOSD患者IL-6与MIF、WBC、ESR、CRP、PLT、SF间均无相关性。结论:MIF在AOSD活动期时显著增高,并与WBC呈正相关,提示MIF可作为AOSD病情活动的血清标志物并参与AOSD发病。
Objective： To examine the level changes of macrophage migration inhibitory factor（ MIF） and interleukin-6（ IL-6） in patients with adult onset Still＇s disease（ AOSD） for preliminary investigation of the pathogenesis of this entity. Methods： The serum levels of MIF and IL-6 were detected with enzyme linked inmmnosorbent assay（ ELISA） in 32 patients with active AOSD patients,26 with stable disease and 20 healthy volunteers. Results： Serum MIF and IL-6 levels in patients with active AOSD were significantly higher than those in stable disease and healthy controls（ P 〈0. 05）. MIF levels were positively correlated with the white cell count（ WBC）,yet showed no correlation with levels of IL-6,erythrocyte sedimentation rate（ ESR）,C-reactive protein（ CRP）,platelet count（ PLT） and serum ferritin（ SF） in patients with active AOSD,and whose IL-6 levels were not correlated with MIF,WBC,ESR,CRP,PLT and SF. Conclusion： MIF was significantly elevated in patients with activity AOSD and positively correlated WBC,suggesting that MIF may be a role in the pathogenesis of AOSD,thus it may be used as a serum marker for estimation of the disease severity.
出处
《皖南医学院学报》
CAS
2014年第3期218-220,共3页
Journal of Wannan Medical College
