摘要
目的探讨研究沙利度胺联合化疗治疗急性白血病的临床疗效以及对血管内皮生长因子(VEGF)、血管内皮生长因子受体(VEGFR)、碱性成纤维细胞生长因子(bFGF)、骨髓微血管密度(MVD)的影响。方法将符合标准的45例急性白血病患者分成观察组(24例)和对照组(21例),每组均进行常规化疗,观察组同时口服沙利度胺100 mg/d。取患者血浆,使用ELISA法测定治疗前后2组患者VEGF、VEGFR、bFGF以及MVD水平以及不良反应的发生情况,比较两种治疗方法的疗效。结果治疗后观察组患者VEGF、VEGFR与MVD分别为(212.8±36.2)pg/ml、(1765.4±338.1)pg/ml、(8.31±1.55)n/HP,与对照组的(289.0±31.7)pg/ml、(1359.9±392.8)pg/ml、(14.21±2.74)n/HP相比差异有统计学意义(P<0.05)。2组患者的bFGF分别为(2.10±0.19)pg/ml与(2.12±0.29)pg/ml,差异无统计学意义(P>0.05)。观察组消化道反应与神经系统症状发生率显著性高于对照组(P<0.05)。结论沙利度胺通过抑制患者体内VEGF的表达与减少MVD而达到治疗急性白血病的目的,值得临床推广并进一步深入研究。
Objective To integrative the clinical effect of thalidomide combined with other chemotherapy drugs in treat- ment of acute leukemia, and its impact on the levels of plasma vascular endothelial growth factor（ VEGF）, vascular endothelial growth factor receptor （ VEGFR）, basic fibroblast growth factor （bFGF） and bone marrow microvascular density （MVD）. Methods Total 25 patients meeting the diagnostic criteria of acute leukemia were recruited and divided into observed group（24 eases） and control group（21 eases）. The chemotherapy was performed in both groups,while the addi- tional thalidomide 100 mg/d was administered in the observed group. The serum levels of VEGF, VEGFR, bFGF and MVD were detected by ELISA before and after the treatment. The adverse reactions were also observed. The therapeutic efficacy was eompared between the two groups. Results The level of VEGF, VEGFR and MVD in the observed group were （ 212.8 ± 36.2） pg/ml, （ 1765.4 ± 338.1 ） pg/ml and （ 8.31 ± 1.55 ） n/HP, respectively, which were significantly dif- ferent from the levels in control group that were （ 289.0 ± 31.7 ） pg/ml, （ 1359.9 ± 392.8 ） pg/ml and （ 14.21 ± 2.74 ） n/HP（P 〈0.05）. There was no significant difference in the level of bFGF between the two groups（P 〉0.05 ）. The incidence of digestive side effects and nervous system symptoms in the observed group were significantly higher than that in control group（ P 〈 0.05 ）. Conclusion Thalidomide can inhibit the expression of VEGF and reduce MVD to treat acute leukemia. It is considered worthy of promotion and further study.
出处
《中华全科医学》
2014年第8期1199-1201,共3页
Chinese Journal of General Practice
关键词
沙利度胺
急性白血病
血管内皮生长因子
骨髓微血管密度
Thalidomide
Acute leukemia
Vascular endothelial growth factor
Bone marrow microvascular density
