摘要
目的分析碳酸锂、米氮平单用联用治疗双相抑郁的疗效。方法将120例双相抑郁患者纳入研究对象,随机分为碳酸锂+米氮平的联合治疗组、单用碳酸锂治疗的碳酸锂组、单用米氮平治疗的米氮平组,观察3组抑郁情绪和社会功能。结果 (1)3组患者HAMD评分均低于治疗前,且联合治疗组HAMD抑郁评均低于碳酸锂组与米氮平组;(2)联合治疗组的职业功能、婚姻职能、父母职能、社会退缩、社会活动、家里活动、家庭职能、自我照顾、关心社会、责任心及SDSS总分均低于碳酸锂组、米氮平组。结论碳酸锂联合米氮平治疗有助于缓解抑郁情绪,改善社会功能,具有积极的临床价值。
Objective To study the efficacy of single use and combined use of lithium carbonate mirtazapine in treating bi-polar depression. Methods Patients with bipolar depression were enrolled and randomly divided into combined treatment group given lithium carbonate ＋ mirtazapine ,lithium carbonate group and mirtazapine group. Then depression emotion and social function were observed. Results After treatment ,HAMA score of three groups were lower than those before therapy ,and HAMA score of combined treatment group were lower than those of lithium carbonate group and mirtazapine group ;Occupa-tion function ,marriage function ,parents function ,social withdrawal ,social activities ,family activities ,family function ,self care ,society care ,responsibility and total SDSS score of combined treatment group were higher than those of lithium carbonate group and mirtazapine group. Conclusion Lithium carbonate combined with mirtazapine has positive clinical value for it can alleviate depression and improve social function.
出处
《中国实用神经疾病杂志》
2014年第9期20-22,共3页
Chinese Journal of Practical Nervous Diseases
关键词
双相抑郁
碳酸锂
米氮平
社会功能
Bipolar depression
Lithium carbonate
Mirtazapine
Social function
