摘要
目的系统评价氨氯地平联合卡托普利治疗高血压病的有效性及安全性。方法检索中国生物医学文献数据库（1978-2013年12月）、中国期刊全文数据库（1994-2013年12月）、维普数据库（1999-2013年12月）、万方数据库（1990-2013年12月）、PUBMED（1990-2013年12月）、Cochrane Libra巧（2013第12期）。纳入氨氯地平联合卡托普利（联合组）与单用卡托普利（单药组）治疗原发性高血压的随机对照试验，由2位研究员独立筛选并提取资料，采用Jadad质量评分评价纳入研究的质量，采用RevMan5．2进行Meta分析。结果共检索到文献355篇，按照纳入和排除标准，最终筛选12篇进行Meta分析。Meta分析结果：联合组有效性高于单药组，差异有统计学意义（OR=4．06，95％CI2．85—5．79，P〈0．01）；联合组不良反应发生率与单药组比较差异无统计学意义（OR=1．35，95％C10．35—5．14，P=0．66）。结论氨氯地平联合卡托普利治疗高血压的疗效优于单用卡托普利，但安全性二者无显著差异。
Objective To assess the efficacy and safety of amlodipine plus captopril for the treatment of essential hypertension. Methods Retrieval review published paper in Chinese Biomedical Literature Database （1978--December, 2013）, China Academic Journal （ 1994--December, 2013 ）, VIP database （1999--December, 2013 ）, Articles Database （ 1990--December, 2013 ）, PUBMED （ 1990--December, 20t 3 ）, Cochrane Library （ December, 2013 ）, Included amlodip- ine and eaptopril （combined group） with captopril alone （monotherapy） treatment of essential hypertension randomized controlled trials, the researchers from the two independent screening and extract data, using Jadad quality score quality of the studies included in the review, using RevMan5.2 for the Meta-analysis. Results 355 papers were retrieved, according to the inclusion and exclusion criteria, finally included 12 paper for Meta-analysis. Meta-analysis： effectiveness of the combined group is higher than the monotherapy group, the difference was statistically significant （ OR = 4.06,95% CI 2.85 - 5.79, P 〈 0, O1 ） ; incidence of adverse reactions in combined group and monotherapy group showed no statistically significant differ- ences （ OR = 1.35, 95% CI 0.35 - 5.14, P = 0.66）. Conclusion Amlodipine combining captopril has better curative effect than single captoprll in the treatment of hypertension, but the safety has no obvious difference
出处
《疑难病杂志》
CAS
2014年第6期627-630,共4页
Chinese Journal of Difficult and Complicated Cases
基金
国家自然科学基金资助项目(No.81270184)
