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TACE治疗不可切除型肝母细胞瘤早期不良反应事件的回顾性分析 被引量:3

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摘要 目的探讨经导管肝动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)治疗儿童不可切除型肝母细胞瘤早期不良反应事件的变化规律及临床意义。方法观察14例不可切除型肝母细胞瘤患儿行TACE治疗前后血清酶学、血常规指标的变化。结果 TACE治疗前后外周血中白细胞(WBC)、血红蛋白(Hb)、血小板(PLT)无显著性变化(P>0.05),不良反应事件较少,等级较低;碱性磷酸酶(ALP)、总胆红素(TBIL)、直接胆红素(DBIL)水平在TACE治疗前后各时间点差异无统计学意义;TACE治疗后3、5 d谷丙转氨酶(ALT)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)水平较治疗前显著升高(P<0.05),ALT、AST不良反应事件增多。TACE治疗后7 d ALT、AST、LDH水平与治疗前差异无统计学意义(P>0.05)。结论 TACE治疗儿童不可切除型肝母细胞瘤仅引发肝功能短暂损伤,在7 d即可实施后续治疗。
出处 《第三军医大学学报》 CAS CSCD 北大核心 2014年第12期1341-1343,共3页 Journal of Third Military Medical University
基金 国家临床重点专科建设项目
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参考文献11

  • 1Trobaugh-Lotrario A D, Katzenstein H M. Chemotherapeutic approa- ches for newly diagnosed hepatoblastoma: past, present, and future strategies [J]. Pediatr Blood Cancer, 2012, 59(5) : 809 -812. 被引量:1
  • 2Otte J B. Progress in the surgical treatment of malignant liver tumors in children [J]. Cancer Treat Rev, 2010, 36(4) : 360 -371. 被引量:1
  • 3Cheng A L, Amarapurkar D, Chao Y, et al. Re-evaluating transarteri- al chemoembolization for the treatment of hepatoeellular carcinoma: Consensus recommendations and review by an International Expert Pan- el [J]. Liverlnt, 2014, 34(2): 174-183. 被引量:1
  • 4Caturell E, Siena D A, Fusilli S, et al. Transcatheter arterial ehemo- embolization for hepatocellular carcinoma in patients with cirrhosis: evaluation of damage to nontumorous liver tissue-long-term prospective study[ J]. Radiology, 2000, 215 ( 1 ) : 123 - 128. 被引量:1
  • 5张成佳,何仕诚,滕皋军,方文,郭金和,邓钢,朱光宇,李国昭.TACE治疗原发性肝癌对肝功能影响的相关因素分析[J].东南大学学报(医学版),2013,32(1):18-22. 被引量:44
  • 6胡显良,吴艳梅,张英姿,张利兵,王珊,陈姬,陈联盟,谭培兰.介入放射学在肝母细胞瘤诊治中的作用评价[J].实用医院临床杂志,2012,9(4):47-49. 被引量:1
  • 7曾承,胡显良,张英姿,张利兵,王珊,陈姬,龚学德,何小兵,陶冲.介入放射学在肝母细胞瘤诊治中的应用[J].中华小儿外科杂志,2010(4):306-308. 被引量:5
  • 8张靖,何小兵,邹炎,余家康,李成昌,石军,周少毅.经导管动脉化疗栓塞联合手术治疗儿童肝母细胞瘤[J].中华小儿外科杂志,2008,29(11):651-653. 被引量:7
  • 9Lencioni R. Chemoembolization for hepatocellular carcinoma [ J ]. Se- rain Oncol, 2012, 39(4) : 503 -509. 被引量:1
  • 10Garwood E R, Fidelman N, Hoch S E, et al. Morbidity and mortality following transarterial liver chemoembolization in patients with hepato- cellular carcinoma and synthetic hepatic dysfunction [ J ]. Liver Transpl, 2013, 19(2) : 164 -173. 被引量:1

二级参考文献34

  • 1钭金法,王金湖,熊启星,李民驹,黄勇,夏彬熊,朱雄凯.不可切除型肝母细胞瘤的术前介入治疗临床研究[J].中华小儿外科杂志,2006,27(7):341-344. 被引量:13
  • 2Vogl TJ, Scheller A, Jakob U, et al. Transarterial chemoembolization in the treatment of hepatoblastoma in children. Eur Radiol, 2006,16: 1393-1396. 被引量:1
  • 3Czauderna P, Zbrzezniak G, Narozanski W, et al. Preliminary experience with arterial chemoembolization for hepatoblastoma and hepatocellnlar carcinoma in children. Pediatr Blood Cancer, 2006,46:825-28. 被引量:1
  • 4Xuewu J, Jianhong L, Xianliang H, et al. Combined treatment of hepatoblastoma with transcatheter arterial chemoembolization and surgery. Pediatr Hematol Oncol, 2006,23:1-9 被引量:1
  • 5Ohtsuka Y, Matsunaga T, Yoshida H, et al. Optimal strategy of preoperative transcatheter arterial chemoembolization for hepatoblastoma. Surg Today, 2004,34: 127-33. 被引量:1
  • 6Tashjian DB, Moriarty KP, Courtney RA, et al. Preoperative chemoembolization for unreseetable hepatoblastoma. Pediatr Surg Int, 2002,18: 187-189. 被引量:1
  • 7Schnater JM,Aronson DC,Plaschkes J,et al.Surgical view of the treatment of patients with hepatoblastoma.Cancer,2002,94(4):1111-1120. 被引量:1
  • 8Carcaller A,Blanchard H,Champagne J,et al.Surgical resection and chemotherapy improve survival rate for patients with hepatoblastoma.J Pediatr Surg,2001,36(5):755-795. 被引量:1
  • 9Udupa KV,Navadgi SM,Mullerpatan P,et al.Neoadjuvant chemotherapy before surgery of hepatoblastoma.Indian J Pediatr,2006,73 (8):735-737. 被引量:1
  • 10Ohtsuka Y,Matsunaga T,Yoshida H,et al.Optimal strategy of preoperative transcatheter arterial chemoembolization for hepatoblastoma.Surg Today,2004,34(2):127-133. 被引量:1

共引文献51

同被引文献31

  • 1胡显良,沈文律,李建宏,蒋学武,陈中献.婴儿肝母细胞瘤的介入治疗及延迟手术治疗[J].实用儿科临床杂志,2004,19(9):793-795. 被引量:5
  • 2钭金法,王金湖,熊启星,李民驹,黄勇,夏彬熊,朱雄凯.不可切除型肝母细胞瘤的术前介入治疗临床研究[J].中华小儿外科杂志,2006,27(7):341-344. 被引量:13
  • 3Aronson DC,Schnater JM,Staalman CR,et al.Predictive value of the pretreatment extent of disease system in hepatoblastoma:results from the international society of pediatric oncology liver tumer study group SIOPEL-1 Study.J Clin Oncol,2005,23:1245-1252. 被引量:1
  • 4Dicken BJ,Bigam DL,Lees GM.Association between surgical margins and long term outcome in advanced hepatoblastoma.J Pediatr Surg,2004,39:721-725. 被引量:1
  • 5Tomayko MM,Reynolds CP.Determination of subcutaneous tumor size in athymic(nude)mice.Cancer chemother pharmacol,1989,24:148-154. 被引量:1
  • 6Matsunaga T,Sasaki F,Ohira M,et al.Analysis of treatment outcome for children with recurrent or metastatic hepatoblastoma.Pediatr Surg Int,2003,19:142-146. 被引量:1
  • 7Brugières L,Branchereau S,Laithier V.Paediatric malignant liver tumours.Bull Cancer,2012,99:219-228. 被引量:1
  • 8Ohtsuka Y,Matsunaga T,Yoshida H,et al.Optimal strategy of preoperative transcatheter arterial chemoembolization for hepatoblastoma.Surg Today,2004,34:127-133. 被引量:1
  • 9Barrena S,Hernandez F,Miguel M,et al.High-risk hepatoblastoma:results in a pediatric liver transplantation center.Eur J Pediatr Surg,2011,21:18-20. 被引量:1
  • 10Meyers RL,Aronson DC,von Schweinitz D,et al.Pediatric liver tumors//Pizzo PA,Poplack DG.Principles and Practice in Pediatric Oncology.Philadelphia,PA,Wolters Kluwer,Lippin-cott,Williams Wilkins,2011:838-860. 被引量:1

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