摘要
目的探讨吡格列酮对不稳定型心绞痛治疗的有效性、安全性和预防心脑血管事件的价值。方法将114例不稳定型心绞痛患者分为2组:治疗组68例,不稳定型心绞痛常规治疗+吡格列酮15mg,每日1次;对照组46例,按不稳定型心绞痛常规治疗。随访1年,观察2组抗心绞痛疗效、心电图改善情况、心脑血管事件及不良反应发生情况。结果治疗组与对照组相比较,能显著改善心绞痛症状(总有效率分别为84%与65%),改善心绞痛的缺血心电图(总有效率分别为91%与78%);治疗组随访1年中复发性心绞痛、心力衰竭均较对照组明显降低(P<0.05),且吡格列酮治疗后不良反应少。结论不稳定型心绞痛应用吡格列酮安全有效,可预防心脑血管事件发生。
Objective To observe the efficacy and safety of pioglitazone in treating unstable angina（UA）and to evaluate its effect on preventing cardiocerebral vascular events.Methods One hundred and fourteen cases with unstable angina were randomly divided into pioglitazone group（n=68）and control group（n=46）.The patients in pioglitazone group received routine anti-UA treatment and pioglitazone（15mg 1times a day）.The patients in control group were treated by routine anti-UA treatment.The efficacy of anti-UA,the change of ECG and cruor-index,the incidence of cardiocerebral vascular events and side effect were observed and evaluated during the followup of one year.Results Pioglitazone could significantly improve the symptoms of angina pectoris.The total effective rate in pioglitazone group and control group were 84%and 65%,respectively（P〈0.05）.Pioglitazone could also significantly improve ischemia ST-T changes in ECG.The total effective rate in pioglitazone group and control group were 91%and 78%,respectively（P〈0.05）.The incidence of recurrent angina pectoris and heart failure ratio of pioglitazone group were less than those in control group（P〈0.05）.The side effect of pioglitazone group was less than that of control group.Conclusion Pioglitazone is effective and safe in treating UAP.It could prevent the occurrence of cardiocerebral vascular events.
出处
《山西医药杂志》
CAS
2014年第11期1240-1242,共3页
Shanxi Medical Journal
