摘要
恐惧消散被认为是一种通过形成新的抑制性学习来拮抗最初的恐惧记忆的复杂过程。目前,通过旨在促进恐惧消散的疗法治疗诸如焦虑症等神经精神疾病已在临床上取得了较好的疗效,因此,如何更有效持久地维持恐惧消散记忆具有重要的意义。围绕与恐惧记忆消散相关的脑区及恐惧记忆消散的分子机制进行阐述,有助于更深入地理解恐惧记忆消散相关的神经生物学机制,为后续研究提供新的方向。
Extinction of fear is considered as a complex process about inhibiting the initial fear memory by learning a new inhibitory memory. Currently clinical treatment of mental illness has a better outcome by facilitation of fear extinction, thereby, it has important significance to make fear extinction more effective and long-lasting. This paper described the fear extinction-related brain areas and the potential molecular mechanisms. It is helpful to further understand the neurobiological mechanisms related to extinction of fear memory.
出处
《生命科学》
CSCD
2014年第6期603-609,共7页
Chinese Bulletin of Life Sciences
基金
国家重点基础研究发展计划("973"项目)(2013CB531303)
国家自然科学基金优秀青年基金项目(81222048)
关键词
恐惧记忆消散
杏仁核
海马
腹内侧前额叶皮层
fear memory extinction
amygdala
hippocampus
ventromedial prefrontal cortex
