摘要
目的探讨老年原发性高血压患者25-羟维生素D水平与动脉僵硬度、左心室肥厚（LVH）的关系。方法选择166例老年原发性高血压患者，测量患者颈股动脉脉搏波传导速度（cfPWV）；超声心动图评价左室质量指数（LVMI），采用电化学发光法测定血清25-羟维生素D水平，根据患者25-羟维生素D水平将患者分为两组，低25-羟维生素D水平组（25-羟维生素D水平〈20μg／L）和高25-羟维生素D水平组（25-羟维生素D水平≥20μg／L）。结果低25-羟维生素D组cfPWV、LVMI值分别为（15．00±3．04）m／s、（120．14±25．82）g／m^2，均高于高25-羟维生素D组（11．26±3．09）m／s、（96．74±23．10）g／m^2（t=-6．79、-5．16，均P=0．000）。多元线性回归分析结果显示，除外年龄、性别的影响，25-羟维生素D水平与LVMI（β=0．215，P=0．001）和cfPWV（β=0．469，P〈0．001）相关。结论血清25-羟维生素D水平与动脉僵硬度、左室肥厚相关，维生素D可能在老年高血压患者动脉僵硬度和左室肥厚中起着重要的作用。
Objective To examine the association of serum 25-hydroxyvitamin D levels with arterial stiffness and left ventricular hypertrophy （LVH） in elderly hypertension patients. Methods We recruited 166 elderly patients [mean age, （80.8 ± 6.2） years] with primary hypertension. Arterial stiffness was assessed by carotid femoral pulse wave velocity （cfPWV）. Left ventrieular mass index （LVMI） was determined according to the Devereux formula. Based on serum 25-hydroxyvitamin D levels, the patients were divided into two groups, the low 25-hydroxyvitamin D group （〈20 μg/L） and the high 25 hydroxyvitamin D group （≥20μg/L）. Results Faster cfPWV and larger LVMI values were observed in the low 25-hydroxyvitamin D group as compared with the high 25- hydroxyvitaminDgroup [（15.00±3.04） m/s vs. （11.26±3.09） m/s;（120.14±25.82） g/m2 vs. （96.74±23.10） g/m2 ; t=-6.79, -5.16, respectively; both P=0. 000]. Multiple liner regression analysis showed that the 25-hydroxyvitamin D level was independently associated with LVMI （β= - 0. 215, P=0. 001） and cfPWV （β=-0. 469, P〈0. 001）. Conclusions Serum 25-hyroxyvitamin D is independently associated with arterial stiffness, LVH Vitamin D may play an important role in the pathogenesis of arterial stiffness and LVH in elderly hypertension patients.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2014年第6期588-590,共3页
Chinese Journal of Geriatrics
关键词
维生素D
动脉粥样硬化
高血压
肥大
左心室
Vitamin D
Atherosclerosis
Hypertension
Hypertrophy, left ventricular
