摘要
目的:骆驼刺胶囊剂为骆驼刺单味药材提取物制备,观察骆驼刺提取物连续灌胃给药13周对大鼠产生的毒性反应。方法:骆驼刺提取物分别以3.0,1.0,0.3 g/kg灌胃给药,每周给药6 d,试验周期为13周,各试验组剩余的1/3动物观察2周恢复期变化。按中药新药长期毒性试验要求观察动物的一般状况、体重变化、血液细胞学及生化学指征、解剖及组织病理学检查。结果:各剂量药组与对照组大鼠比较,血液及生化指标与对照组相比无明显差异,脏器未出现给药相关的病变。结论:骆驼刺提取物长期灌胃3g/kg未见毒性反应。
Objective： To observe the toxicity of continuous oral administration of Alhagi sparsifolia shap（ L.） extract in rats. Methods： Rats were randomly divided into 3 groups,each group was given Alhagi sparsifolia shap（ L.） extract intragastrically in dose of 3. 0,1. 0,0. 3 g /kg for13 weeks. Parameters were examined including general condition,body weight,food intake,blood cell,blood biochemistry,organ index,and pathological changes. Results： Each drug group compared with the control had no significant differences in weight,organ coefficient,the indexes of haematology and biochemistry,pathological changes between the two groups. Conclusion： Alhagi sparsifolia shap（ L.） extract has no significant toxicity for long-term oral administration to rats,which can be used safely.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2014年第2期113-115,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
新疆维吾尔自治区科技成果转化专项资金项目(201154129)
科技创新种子资金项目(K111410001)
关键词
骆驼刺提取物
大鼠
长期毒性
Alhagi sparsifolia shap（L.） extract（骆驼刺胶囊）
long-term toxicity
rats
