摘要
目的:通过观察葛藤分散片对去卵巢骨质疏松大鼠模型的影响,阐述其对骨质疏松症的作用机理,为临床应用提供药效学依据。方法:Wistar大鼠手术切除双侧卵巢3天后,按照体重随机分组,每天灌胃葛藤分散片200mg/kg、100mg/kg和50mg/kg,并设模型组,假手术组和尼尔雌醇阳性对照组,给药6个月后,测定大鼠骨密度,股骨力学性能,骨质量和体积比值,BGP,25-HVD,BAP,CTX-I和TRAP5b水平等指标。结果:葛藤分散片3个给药组均明显提高骨组织抗外力作用,其中以200mg/kg组作用最为明显;不同给药组不同程度改善造模引起的骨质疏松表现,3个剂量组均具有显著性统计学差异,其中200mg/kg组作用最显著。结论:考察了葛藤分散片对去卵巢骨质疏松模型的治疗作用,证明了葛藤分散片对雌激素缺乏引起的骨质疏松症具有明显的改善作用,为临床应用提供药效学依据。
Objective： By observing pueraria iobata dispersible tablet on Influence of osteoporosis in ovariectomized rat model to explain the mechanism of its role in the treatment of osteoporosis,basis for clinical Pharmacodynamics of applications. Methods： Wistar rat,3 days after the resection of bilateral ovarian,in accordance with the random grouping of weight,A day after intragastric pueraria lobata dispersible tablets200mg /kg,100mg /kg,50mg /kg,Set up model group,operations group and nilestriol the positive control group,6months after delivery,of Bone Mineral Density in rats,mechanical properties of the femur,bone mass and volume ratios,such as bgp,25-hvd,bap,ctx-i and trap5b level indicator. Results： Pueraria lobata dispersible tablets three administration groups are significantly improved bone tissue Resistance Forces,In the most obvious high dose effects; Different groups of osteoporosis caused by different levels to improve model performance,All three dose groups with significant statistical difference（ P ＆lt; 0. 01）,high dose effects of the most significant. Conclusion： This article from the perspective of many different level study of pueraria lobata dispersible tablet on therapeutic effect of ovariectomized osteoporosis model,evidence of pueraria lobata dispersible tablet on osteoporosis induced by estrogen deficiency has an obvious effect,basis for clinical pharmacodynamics of applications.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2014年第2期87-89,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
山东省科技攻关项目(№:2007GG2NS02077)
关键词
葛藤分散片
骨质疏松症
大鼠
雌激素
生物力学
Pueraria lobata dispersible tablets（葛藤分散片）
osteoporosis
estrogen
biomechanics
rat
