摘要
目的:观察双虎胶囊治疗良性前列腺增生症(肾虚血瘀型)的临床疗效及安全性。方法:采用随机、对照的方法,选取BPH(肾虚血瘀型)患者72例,其中治疗组和对照组各36例。经过1个疗程(12 w)治疗后,观察各组患者治疗前后中医证侯积分、国际前列腺症状评分(I-PSS)、生活质量评分(QOL)及最大尿流率的变化。所有结果均采用SPSS 17.0进行统计分析,P≤0.05表示差异有统计学意义。结果:治疗组临床控制9例,显效12例,有效9例,无效3例,控显率63.64%,总有效率90.91%,相比对照组(控显率47.06%,总有效率82.35%),2组疗效比较差异无统计学意义(P>0.05)。与对照组比较,治疗组在减少中医证候积分、增加最大尿流率方面疗效优于对照组,差异具有统计学意义(P<0.05)。结论:双虎胶囊用于治疗BPH(肾虚血瘀型)临床有效,疗效等同于癃闭舒胶囊。双虎胶囊能有效缓解临床症状,减少中医证候积分,增加最大尿流率,提高患者生活质量,且未见明显不良反应,可作为治疗本病的一种良好选择。
Objective： To observe the Shuang-hu capsule treating benign prostatic hyperplasia （kidney deficiency and blood stasis type） in the elinical efficacy and safety. Methods ： With the randomized and controlled method, 72 patients of benign prostatic hyperplasia （kidney deficiency and blood stasis type） were selected, 36 cases in the treatment group （Shuang-hu capsule ）, while 36 cases in the control group （Long-bi-shu capsule ） . After a course of treatment （12 weeks）, each group was observed in TCM symptom score, international prostate symptom score （I-PSS）, quality of life score （QOL） and maximum flow rate （Qmax） changes of detection before and after the treatment. All results are used SPSS17.0 statistical analysis, and P≤0. 05 indicated that the difference was statistically significant. Results： In the treatment group, 9 cases were cured completely, 12 cases were effective, 9 cases marks got improved and 3 cases were ineffective. The total effective rate, marked improvement rate were 90. 91% and 63.64% respective-ly. Meanwhile the total effective rate, marked improvement rate were 82. 35% and 47. 06% respectively in the control group. The com- parison of curative effect between the two groups, the difference was not statistically significant （P 〉 0. 05 ） . Compared with the con- trol group, in the TCM symptom score and maximum flow rate （Qmax）, treatment group was more effective than the control group, the difference was statistically significant （P 〈 0.05 ） . Conclusion： Shuang-hu capsule was effective in the treatment of benign pros- tatic hyperplasia （kidney deficiency and blood stasis type） and there was same result compared with Long bishu capsule. It could re- lieve the clinical symptoms, reduce the TCM symptom score, increase the maximum flow rate （Qmax）, enhance the quality of life, and without any obvious side effects.
出处
《成都中医药大学学报》
2014年第2期86-89,共4页
Journal of Chengdu University of Traditional Chinese Medicine
基金
成都中医药大学附属医院院基金课题(编号:2010-D-YY-01)
关键词
双虎胶囊
肾虚血瘀
良性前列腺增生
临床研究
Shuang-hu capsule
kidney deficiency and blood stasis
benign prostatic hyperplasia
clinical research
