摘要
目的观察米库氯铵与琥珀胆碱、阿曲库铵在无抽搐电休克治疗（MECT）中的应用。方法选择精神分裂症患者60例，年龄18-60岁，ASAⅠ或Ⅱ级，随机分为米库氯铵组（A组）、琥珀胆碱组（B组）和阿曲库铵组（C组），每组20例。分别观察记录诱导后肌松药起效时间、MECT后自主呼吸恢复时间、患者完全清醒时间及MECT诱导前和治疗后5minMAP、HR、SpO2的变化。结果B组肌松起效时间、自主呼吸恢复时间明显短于A组和C组（P〈0．05）。A组肌松起效时间、自主呼吸恢复时间明显短于C组（P〈0．05）。结论在无琥珀胆碱或应用琥珀胆碱禁忌的情况下，米库氯铵是行MECT较好替代药物。
Objective To observe the effect of mivacurium, succinylcholine and atracurium in modified electric convulsive therapy （MECT）. Methods Sixty ASA Ⅰ or Ⅱpatients with schizo- phrenia aged from 18 to 60 years old were randomly divided into 3 groups ： mivacuriumgroup （group A, n=20）, succinylcholine group （group B, n=20）, atracurium group （group C, n=20）. The onset time of muscle relaxation, the recovery time of spontaneous breathing after MECT, the awake time, as well as the changes of 5 rain MAP, HR and SpO2 before and after MECT were observed respectively. Results The onset time of muscle relaxation and the recovery time of spontaneous breathing in group B were shorter than those in groups A and C （P〈0.05）. The onset time of muscle relaxation and the recovery time of spontaneous breathing in group A were shorter than those in group C （P〈0.05）. Conclusion Mivacurium is a better alternative medicine in MECT in the situation of no succinylcholine or succnylcholine contraindication.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2014年第6期584-585,共2页
Journal of Clinical Anesthesiology
关键词
米库氯铵
琥珀胆碱
阿曲库铵
无抽搐电休克
Mivacurium
Suecinylcholine
Atracurium
Modified electric convulsive therapy
