摘要
目的 :了解急、慢性肝炎及肝硬化患者血清转化生长因子 β1(transforminggrowthfactorβ1,TGFβ1)水平的变化 ,探讨TGFβ1在肝纤维化、肝硬化发病中的作用。方法 :采用标准的生物学方法即TGFβ1对水貂肺上皮细胞生长抑制的方法测定 89例肝病患者和 2 4例正常人血清TGFβ1含量。结果 :①急性肝炎患者血清TGFβ1水平 (1 91± 0 48ng/ml)与正常对照组 (1 6 5± 0 45ng/ml)比较无明显差异 (P >0 0 5 ) ;②慢性肝炎及肝硬化患者血清TGFβ1水平 (5 6 2± 1 0 2ng/ml,11 75± 1 0 8ng/ml)均明显高于正常对照组 (P <0 0 5 ) ,且肝硬化患者比慢性肝炎患者增高更明显 (P <0 0 5 )。结论 :慢性肝炎及肝硬化患者TGFβ1分泌增加 ,且肝硬化比慢性肝炎患者增加更明显 ;而急性肝炎患者TGFβ1分泌无明显变化。TGFβ1在一定程度上反映了肝纤维化的程度 ,在肝纤维化、肝硬化病理过程中具有重要意义。TGFβ1可望作为肝纤维化的标志物。TGFβ1拮抗剂有望成为肝纤维化治疗的重要药物。
Objective:To investigate the variation of serum transforming growth factor β 1 (TGF β 1) in patients with acute hepatitis,chronic hepatitis and liver cirrhosis and the role of TGF β 1 in the pathophysiologic process of liver fibrosis and cirrhosis.Methods:Serum TGF β 1 was detected by using a standard bioassay in 89 patients with liver disease (acute hepatitis 32,chronic hepatitis 22 and liver cirrhosis 35) and 20 healthy persons served as normal control.Results:The data showed that (1)the serum TGF β 1 in patients with acute hepatitis (1 91±0 48 ng/ml) were similar with those in controls (1 65±0 45 ng/ml, P >0 05);(2)the serum TGF β 1 in patients with chronic hepatitis (5 62±1 02 ng/ml) and liver cirrhosis (11 75±1 08 ng/ml) were significantly higher than those in controls ( P <0 05),and the serum TGF β 1 were higher in the patients with liver cirrhosis than those in chronic hepatitis ( P <0 05).Conclusions:We suggested there was no change of the serum TGF β 1 in patients with acute hepatitis,the serum TGF β 1 were significantly higher in chronic hepatitis and liver cirrhosis and those were higher in the patients with liver cirrhosis than those in chronic hepatitis.The TGF β 1 may reflect the severity of liver cirrhosis.The TGF β 1 play the role in the pathophysiologic process of liver fibrosis and cirrhosis.We suggested the TGF β 1 may be a mark of liver fibrosis and the blocker of the TGF β 1 may be a important drug in the treatment of liver fibrosis.
出处
《华西医学》
CAS
2001年第1期46-48,共3页
West China Medical Journal
基金
四川省卫生厅资助课题!(F0 1 4 3)
