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自杀候选基因的影像学研究进展

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摘要 自杀已经成为国内外日益严重的公共卫生问题.Phillips等[1]对中国1995至1999年自杀死亡及自杀未遂的研究得出自杀是我国第五位重要的死亡原因.自杀问题的研究也越来越受到关注.目前关于自杀的遗传学病因研究较多,但遗传学研究并未发现自杀的致病基因也存在研究结果不一致的情况[2].脑功能成像技术为研究大脑的高级精神活动提供了新的方法,但功能影像学研究也没有得出一致的结论.基因影像学(Imaging Genetics)方法将基因与影像学结合,运用生理影像技术作为表型分析来评价基因的变异情况,从而探讨基因是如何影响大脑的神经结构和功能,以及由此导致的心理问题.目前对自杀行为的基因影像学研究尚未深入,主要是针对其候选基因多态性的影像学进行研究,本文选取了与自杀行为相关的候选基因的神经影像学研究进展作一综合描述.
作者 陈小容 况利
出处 《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2014年第5期479-480,共2页 Chinese Journal of Behavioral Medicine and Brain Science
基金 国家自然科学基金(81071118) 卫生部公益行业科研专项(201002003) 重庆市科委重点项目(CSTC 2011BA5040) 重庆市卫生局项目(2009-1-55)
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参考文献26

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