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血清标记物在胃肠胰神经内分泌肿瘤诊治中的价值 被引量:3

Application of serum biomarkers in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasm
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摘要 胃肠胰神经内分泌肿瘤(gastroenteropancreatic neuroendocrine neoplasm,GEP-NENs)是一组起源于消化系统神经内分泌细胞具有显著异质性的少见肿瘤。常规消化系统肿瘤标记物在GEP-NENs中通常不升高,加之GEP-NENs早期常缺乏特异性临床表现,肿瘤获得诊断时约50%已出现局部进展或远处转移。因此,寻找和发现能够对GEP-NENs进行诊断、治疗评价及进展监测的血清生物标记物(biomarkers),成为诊治GEP-NENs的一项重要任务。目前,对GEP-NENs诊断及治疗有实用价值的血清标记物中,功能性GEP-NENs分泌的特异性激素可作为其特异性的血清标记物,而嗜铬素A作为非特异性的"通用"标记物,是目前GEP-NENs的临床诊断和疗效评价中最重要的血清标记物。 Gastroenteropancreatic neuroendocrine neoplasm (GEP-NENs) is a heterogeneous group of tumour arising from neuroendocrine cells in the digestive system. Since regular tumor markers used in neoplasms of the digestive system are scarcely beyond normal range in GEP-NENs, together with the silent clinical manifestation at the early stage of the disease, 50% of GEP-NENs patients present with advanced disease when diagnosed. Therefore, it is critical to find effective circulating biomarkers for the diagnosis of GEP-NENs, as well as to assess treatment efficacy and monitor progression. Among practical serum biomarker for GEP-NENs diagnosis and treatment, hormones secreted by functional GEP-NENs are served as specific serum markers. The non-specific "universal" biomarker chromogranin A is the most important serum marker at present, which is of great value in diagnosis and treatment of GEP-NENs.
作者 陈洁 杨秋辰
出处 《中国实用外科杂志》 CSCD 北大核心 2014年第6期499-503,共5页 Chinese Journal of Practical Surgery
关键词 血清标记物 胃肠胰神经内分泌肿瘤 嗜铬素A serum biomarker gastroenteropancreatic neuro-endocrine neoplasm chromogranin A
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  • 1岳欣,顾锋,夏维波,萧新华,李梅,邢小平,曾正陪,向红丁,连小兰,伍学焱.胰岛素瘤的术前定性及定位诊断99例分析[J].中国实用内科杂志:临床前沿版,2006,26(11):1795-1797. 被引量:16
  • 2中国胃肠胰神经内分泌肿瘤病理专家组.中国胃肠胰神经内分泌肿瘤病理学诊断共识[J].中华病理学杂志,2011,. 被引量:11
  • 3Eriksson B, Oberg K, Stridsberg M. Tumor markers in neuroendoerine tumors. Digestion, 2000, 62 Suppl 1: 33- 38. 被引量:1
  • 4Oberg K. Biochemical diagnosis of neuroendocrine GEP tumor. Yale J Biol Med, 1997, 70 (5-6): 501-508. 被引量:1
  • 5Ardill JE, Erikkson B. The importance of the measurement of circulating markers in patients with neuroendocrine tumours of the pancreas and gut. Endocr Relat Cancer, 2003, 10 (4): 459-462. 被引量:1
  • 6Modlin IM, Latich I, Zikusoka M, et al. Gastrointestinal carcinoids: the evolution of diagnostic strategies. J Clin Gastroenterol, 2006, 40 (7): 572-582. 被引量:1
  • 7Bemini GP, Moretti A, Ferdeghini M, et al. A new human chromogranin ‘A' immunoradiometric assay for the diagnosis of neuroendocrine tumours. Br J Cancer, 2001, 84 (5): 636-642. 被引量:1
  • 8Campana D, Nori F, Piscitelli L, et al. Chromogranin A: is it a useful marker of neuroendocrine tumors? J Clin Oncol, 2007, 25 (15): 1967-1973. 被引量:1
  • 9Kolby L, Bernhardt P, Sward C, et al. Chromogranin A as a determinant of midgut carcinoid tumour volume. Regul Pept, 2004, 120 (1-3): 269-273. 被引量:1
  • 10Seregni E, Ferrari L, Stivanello M, et al. Laboratory tests for neuroendocrine tumours. Q J Nucl Med, 2000, 44 (1): 22-41. 被引量:1

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