摘要
胃肠胰神经内分泌肿瘤(gastroenteropancreatic neuroendocrine neoplasm,GEP-NENs)是一组起源于消化系统神经内分泌细胞具有显著异质性的少见肿瘤。常规消化系统肿瘤标记物在GEP-NENs中通常不升高,加之GEP-NENs早期常缺乏特异性临床表现,肿瘤获得诊断时约50%已出现局部进展或远处转移。因此,寻找和发现能够对GEP-NENs进行诊断、治疗评价及进展监测的血清生物标记物(biomarkers),成为诊治GEP-NENs的一项重要任务。目前,对GEP-NENs诊断及治疗有实用价值的血清标记物中,功能性GEP-NENs分泌的特异性激素可作为其特异性的血清标记物,而嗜铬素A作为非特异性的"通用"标记物,是目前GEP-NENs的临床诊断和疗效评价中最重要的血清标记物。
Gastroenteropancreatic neuroendocrine neoplasm (GEP-NENs) is a heterogeneous group of tumour arising from neuroendocrine cells in the digestive system. Since regular tumor markers used in neoplasms of the digestive system are scarcely beyond normal range in GEP-NENs, together with the silent clinical manifestation at the early stage of the disease, 50% of GEP-NENs patients present with advanced disease when diagnosed. Therefore, it is critical to find effective circulating biomarkers for the diagnosis of GEP-NENs, as well as to assess treatment efficacy and monitor progression. Among practical serum biomarker for GEP-NENs diagnosis and treatment, hormones secreted by functional GEP-NENs are served as specific serum markers. The non-specific "universal" biomarker chromogranin A is the most important serum marker at present, which is of great value in diagnosis and treatment of GEP-NENs.
出处
《中国实用外科杂志》
CSCD
北大核心
2014年第6期499-503,共5页
Chinese Journal of Practical Surgery
关键词
血清标记物
胃肠胰神经内分泌肿瘤
嗜铬素A
serum biomarker
gastroenteropancreatic neuro-endocrine neoplasm
chromogranin A