摘要
microRNA(miRNA)是一类存在于真核细胞中的非编码小RNA,可以调控基因转录后表达。人体中30%以上的基因都受miRNA的调控,同时miRNA还可作为不同生理和病理状态的分子标记。尽管已经在各种生物中预测并证实了数百种miRNA,但miRNA及其靶基因的明确作用机制和功能尚不完全明了。许多研究表明,miRNA与肺部疾病感染的发生、发展及转化有着密切的关联。miRNA在肺部疾病的正负调节功能为细菌性肺部疾病的诊断和治疗提供了新方向。我们简述了miRNA在潜伏性肺结核病和活动性肺结核病诊断领域的研究进展。
microRNA（miRNA） is a newly discovered class of non-coding small RNA in the eukaryotic cells, which can regulate gene expression after transcription. More than 30% of genes are regulated by miRNA in the human body, and miRNA were regarded as molecular markers of different physiological and pathological states. Although hundreds of miRNA have been predicted and confirmed by people, it is not fully understand about the mechanism and function between miRNA and its target genes. Many studies have shown that miRNA are closely linked with infection, development and transformation of lung disease, miRNA that have positive and negative regulatory function in the lung disease can provide a new direction for the diagnosis and treatment of baeterial lung disease. We described the miRNA research progress in the diagnosis of latent tuberculosis and active tuberculosis.
出处
《生物技术通讯》
CAS
2014年第3期433-435,共3页
Letters in Biotechnology
