关于子痫前期研究的三类动物模型的进展
摘要
子痫前期（preeclampsia,PE）是常见的妊娠期特有的疾病,是孕产妇和围产儿发病及死亡的主要原因.关于PE的病因及发病机制仍不清楚,经多年研究后,提出了多种病理生理学机制,近年的大量研究认为,其发病主要与胎盘血管形成障碍、胎盘氧化应激反应及母体异常免疫反应有关.因此,有PE特征表型的动物模型已成为研究PE病因及探索PE治疗方法的重要工具.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2014年第5期389-391,共3页
Chinese Journal of Obstetrics and Gynecology
参考文献22
-
1Wildman DE, Chen C, Erez O, et al. Evolution of the mammalian placenta revealed by phylogenetie analysis [ J ]. Proe Natl Acad Sci U S A, 2006, 103:3203-3208. 被引量：1
-
2Mess A, Zaki N, Kadyrov M, et al. Caviomorph placentation as a nmdel for trophoblast invasion [ J ]. Placenta, 2007, 28: 1234- 1238. 被引量：1
-
3Snares M J, Chakraborty D, Karim Rumi MA, et al. Rat placentation : an experimental model for investigating the hemochorial maternal-fetal interface [ J ]. Placenta, 2012, 33: 233 -243. 被引量：1
-
4AI-Khan A, Aye IL, Barsoum I, et al. IFPA Meeting 2010 Workshops Report II :Placental pathology; trophoblast invasion; fetal sex; parasites and the placenta; decidua and embryonic or fetal loss; trophoblast differentiation and syncytialisation [ J ]. Placenta, 2011, 32:$90-99. 被引量：1
-
5Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia [ J ]. N Engl J Med, 2004, 350:672-683. 被引量：1
-
6Levine ILl, Lain C, Qian C, et al. Soluble endogliu and other circulating antiangiogenic factors in preeclampsia [ J ]. N Engl J Med, 2006, 355:992-1005. 被引量：1
-
7Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 ( sFltl ) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia[ J ]. J Clin Invest, 2003, 111:649-658. 被引量：1
-
8Venkatesha S, Toporsian M, Lam C, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia [ J ]. Nanure Medicine, 2006, 12:642-649. 被引量：1
-
9Yang F, Jin C, Jiang YJ, et al. Potential role of soluble VEGFR- 1 in antiangiogenesis therapy for cancer [ J ]. Expert Rev Anticancer Ther, 2011, 11:541-549. 被引量：1
-
10Li J, LaMarca B, Reckelhoff JF. A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model[ J]. Am J Physiol Heart Circ Physiol, 2012, 303 :H1-8. 被引量：1
二级参考文献15
-
1Sugerman HJ. Hypothesis: preeclampsia is a venous diseasesecondary to an increased intra-abdominal pressure. MedHypotheses, 2011,77:841-849. 被引量：1
-
2Dai Y, Diao Z? Sun H,et al. MicroRNA-155 is involved inthe remodelling of human-trophoblast-derived HTR-8/SVneocells induced by lipopolysaccharides. Hum Reprod, 2011,26:1882-1891. 被引量：1
-
3Faas MM, Broekema M,Moes H, et al. Altered monocytefunction in experimental preeclampsia in the rat. Am JObstet Gynecol, 2004,191 : 1192-1198. 被引量：1
-
4Li L. Kang J,Lei W. Role of Toll-like receptor 4 ininflammation-induced preterm delivery. Mol Hum Reprod,2010, 16:267-272. 被引量：1
-
5Cardenas I,Mor G,Aldo P, et al. Placental viral infectionsensitizes to endotoxin-induced pre-term labor: a double hithypothesis. Am J Reprod Immunol? 2011,65:110-117. 被引量：1
-
6Koga K,Aldo PB, Mor G. Toll-like receptors andpregnancy: trophoblast as modulators of the immuneresponse. J Obstet Gynaecol Res,2009,35 : 191-202. 被引量：1
-
7Faas MM, Schuiling GA,Bailer JF, et al. A new animalmodel for human preeclampsia : ultra-low-dose endotoxininfusion in pregnant rats. Am J Obstet Gynecol? 1994? 171 :158-164. 被引量：1
-
8Wang B,Koga K,Osuga Y,et al. High mobility group box1 ( HMGB1 ) levels in the placenta and in serum inpreeclampsia. Am J Reprod Immunol, 2011,66; 143-148. 被引量：1
-
9Gandley RE, Rohland J, Zhou Y, et al. Increasedmyeloperoxidase in the placenta and circulation of womenwith preeclampsia. Hypertension* 2008,52:387-393. 被引量：1
-
10Zhang Y,Hua Z, Zhang K,et al. Therapeutic effects ofanticoagulant agents on preeclampsia in a murine modelinduced by phosphatidylserine/phosphatidylcholine micro-vesicles. Placenta, 2009’ 30:1065-1070. 被引量：1
-
1闫素玲,刘素萍,多云莲.子痫前期患者应用硫酸镁与拉贝洛尔的观察与护理[J].中国实用医药,2012,7(1):206-207. 被引量：7
-
2曹霞.使用药物是否存在个体差异[J].医药与保健,2001,0(4):18-18.
-
3肖俊杰,成燕,詹青.慢性脑缺血导致认知障碍的病理生理学机制[J].国际脑血管病杂志,2009,17(8):614-617. 被引量：5
-
4陈国栋,周志明.卒中后抑郁的病理生理学机制[J].国际脑血管病杂志,2014,22(5):397-400. 被引量：13
-
5黄小玲,王自能.子痫前期发病机制探讨[J].中华围产医学杂志,2008,11(6):422-425. 被引量：1
-
6王化廷,王兆兰,吴爱华,尹爱丽.阿托品治疗胎儿窘迫疗效分析(附432例报告)[J].山东医药,2002,42(1):42-43.
-
7丘蔚萍,尹培达.风湿性疾病 第七讲 血管炎的诊断及治疗[J].新医学,1994,25(12):652-653.
-
8杨彩梅,王洁,李雪斌.卒中后抑郁的病理生理学机制[J].国际脑血管病杂志,2016,24(4):349-355. 被引量：8
-
9刘力,张岩.浅谈药物的合理应用[J].世界核心医学期刊文摘（眼科学分册）,2004(1):982-983.
-
10赵强,王彩霞.中药提取物对脑缺血药理学研究进展[J].实用药物与临床,2005,8(6):46-48. 被引量：1
