摘要
目的 探讨前列腺素E1 抗肝纤维化作用及治疗慢性肝炎的疗效观察。方法 治疗组29例 (男26例、女3例 ;平均年龄35±14岁 )在综合治疗基础上加用前列腺素E10.1mg加入10 %葡萄糖250ml中静滴 ,gd×20天 ;对照组31例 (男27例 ,女4例 ,平均年龄36±13岁 )在综合治疗基础上加用促肝细胞生长素100mg静滴 ,gd×20天。结果 治疗组HA、LN、IV -C及PCⅢ均明显降低 (P均<0.01)而对照组降低不明显 (P均>0.05)。在改善肝功能方面的疗效与对照组相似 (P均>0.05)。结论 前列腺素E1 既有良好的护肝作用 ,又有抗肝纤维化作用。
Objective To Explore the efficacy of prostaglandin E1 in treating hepatic fibrosis. Methods 29 patients were treated with prostaglandin E1, the other 31 patients were treated with hepatocyte growth factor (HGF) as control. Results HA, LN, IV-C and PC III levels of prostaglandin E1 group decreased significantly (p<0.01), but that of HGF group didn't decrease (p>0.05). They had similar effects on improving liver function (p>0.05). Conclusion Prostaglandin E1 could improve liver function and had anti-hepatic fibrosis effect.
出处
《浙江临床医学》
2001年第3期159-160,共2页
Zhejiang Clinical Medical Journal