摘要
目的观察美他多辛联合多烯磷脂酰胆碱治疗酒精性肝病的疗效。方法 70例酒精性肝病住院患者随机分为治疗组和对照组各35例,两组一般治疗相同,对照组用多烯磷脂酰胆碱针,治疗组在对照组基础上加用美他多辛片。所有患者均于治疗前、后检查血清生化指标中的丙氨酸氨基转移酶(ALT)、清天冬氨酸氨基转移酶(AST)、总胆红素(TBil)、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、结合胆红素(DBil),并记录临床症状和体征变化,进行肝脏彩超检查,评价临床疗效。结果 4周后,治疗组患者的疗效明显高于对照组。2组治疗后肝功能各项指标均较治疗前显著降低,治疗组治疗后肝功能各项指标均明显低于对照组治疗后。治疗组轻、中、重度脂肪肝的改善情况明显优于对照组。结论美他多辛和多烯磷脂酰胆碱联用疗效优于单用多烯磷脂酰胆碱。
Objective To explore the clinical effect of metadoxine combined with polyene phosphatidyl choline on the treatment of patients with alcoholic liver disease （AID）. Methods 70 patients with AID were randomly divided into treatment group and control group, 35 cases in each group. On the basis of conventional therapy in both groups, the control group was treated with polyene phosphatidyl choline and treatment group was treated with metadoxine tablet combined with polyene phosphatidyl choline. Serum alanine aminotransferase （A IT）, aspartate aminotransferase （AST）, total bilirubin （TBil）, glutamyltranspeptidase （GGT）, alkaline phosphatase （ALP） and conjugative bilirubin （DBil） before and after treatment were observed in both groups, and changes of clinical symptoms and physical signs were recorded, color ultrasound of liver was conducted and clinical efficacy was evaluated. Results 4 weeks after treatment, clinical efficacy in treatment group was significantly higher than control group. Every index of liver function in both groups decreased significantly, and the indexes in the treatment group were significantly lower than the control group. Improvements of mild, moderate and severe fatty liver in the treatment group were significantly better than those in the control group. Conclusion Metadoxine combined with polyene phosphatidyl choline is more effective than single polyene phosphatidyl choline in treating AID.
出处
《实用临床医药杂志》
CAS
2014年第5期87-89,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321644)
关键词
酒精性肝病
多烯磷脂酰胆碱
美他多辛
脂肪肝
alcoholic liver disease
polyene phosphatidyl choline
metadoxine
fatty liver
