摘要
目的评价脑心通胶囊联合低分子肝素钙对急性冠脉综合征患者血清hs-CRP、IL-6及血脂的影响。方法88例老年急性冠脉综合征患者,随机分为对照组和观察组,每组44例。对照组采用常规治疗;观察组在对照组常规治疗方式基础上,加用低分子肝素钙注射液及脑心通胶囊治疗。结果经过治疗,观察组患者LVEF、CO、E/A的改善情况显著优于对照组,差异有统计学意义(P<0.01或0.05)。治疗后观察组心绞痛发作次数及持续时间分别为(1.9±0.5)次、(1.6±0.4)min,少于对照组的(4.5±1.3)次、(4.8±1.2)min,差异有统计学意义(P<0.01)。治疗后观察组患者CHOL、TG及LDL-C分别为(5.13±0.53)mmol/L、(2.34±0.55)mmol/L、(2.15±0.65)mmol/L,低于对照组的(6.36±0.58)mmol/L、(3.57±0.88)mmol/L、(3.16±0.33)mmol/L,差异有统计学意义(P<0.01)。治疗后观察组患者血清IL-6、hs-CRP分别为(6.64±2.1)ng/L、(3.3±1.1)mg/L,低于对照组的(8.25±2.2)ng/L、(4.2±1.3)mg/L,差异有统计学意义(P<0.01或P<0.05)。结论脑心通胶囊联合低分子肝素钙治疗急性冠脉综合征疗效显著,并能改善患者血清hs-CRP和IL-6及血脂水平。
Objective To study the effect of naoxintong capsule combination nadroparin calcium on serum hs-CRP, IL-6 and lipids of patients with acute coronary syndrome. Methods A total of 88 cases of eider patients with acute coro-nary syndrome,were randomly divided into control group and observation group, each of 44 patients. Control grouppatiewts were given conventional therapy. Observation group were added nadroparin calcium injection and naoxintongcapsule treatment on the basis of control group＇s conventional therapy. Results After treatment, the improvement ofLVEF, CO,E/A in observation group were obviously better than control group, the difference had statistic significance（P〈0.01）. The attack frequency and duration of angina pectoris in observation group were （1.9±0.5） times every （1.6±0.4）min, which was lower than （4.5±1.3） times every （4.8±l.2）min, the difference had statistic significance （P〈0.01 ）. Total cholesterol, triglyceride and low density lipoprotein cholesterol in observation group Were respectively （5.13±0.53 ）mmol/L, （2.34±0.55）mmol/L, （2.15±0.65）mmol/L, which were lower than （6.36±0.58）mmol/L, （3.57±0.88）mmol/L,（3.16±0.33）mmol/L in control group, the difference had statistic significance（P〈0.01）. Serum IL-6, hs-CRP in ob-servation group were respectively （6.64±2.1）ng/L, （3.3±1.1）rag/L, which were lower than （8.25±2.2）ng/L, （4.2±1.3）mg/L in control group, the difference had statistic significance （P〈0.01 or P〈0.05）. Conclusion Naoxintong capsule incombination with nadroparin calcium＇s treatment to patients with acute coronary syndrome is remarkable, and it canmake patients＂ serum hs-CRP and IL-6 and lipid better.
出处
《中国现代医生》
2014年第17期8-11,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划(2012ZHB017)
关键词
脑心通胶囊
低分子肝素钙
急性冠脉综合征
高敏C反应蛋白
白细胞介素6
血脂
Naoxintong capsule
Nadroparin calcium
Acute coronary syndrome
High-sensitivity C-reactive protein
Interleukin-6
Blood lipid
