摘要
目的：评价局部应用氯胺酮对气管内插管术后咽喉痛（postoperativesolethroat，POST）的效果及安全性。方法：网络检索相关中英文数据库，选取局部应用氯胺酮预防POST的临床文献。采用Stata12．0软件完成Meta分析，计算POST相对危险度（riskratio，RR）和95％可信区间（confidenceinterval，CI）。结果：共纳入7项研究，490例患者。以固定效应模型合并统计量，结果显示：与对照组相比，局部应用氯胺酮组的术后0—1h，4h及24h咽喉痛的发生率显著降低，RR分别为0．61（95％CI0．47—0．79，P〈0．001），0．55（95％CI0．43—0．71，P〈0．001）和0．48（95％CI0．34—0．66，P〈0．001）。纳入的文献均未观察到与局部应用氯胺酮相关的不良反应。结论：局部应用氯胺酮能安全有效地降低POST的发生率，效果可达24h。
Objective To evaluate the influence and safety of topical ketamine on postoperative sore throat following endotracheal intubation. Methods The clinical literatures concerning topical application of ketamine for the prevention of postoperative sore throat （POST） were searched from online databases. Randomized controlled trials were selected by the inclusive and exclusive criteria. Meta-analysis was conducted to assess the risk ratio （RR） of the incidence of POST and software Stata 12.0 was used in this analysis. Results Seven randomized trials involving 490 patients were included in this meta-analysis. The results of meta-analysis showed that the incidence of POST was significantly reduced in the ketamine group, with RR 0.61 （95%CI 0.47 - 0.79, P 〈 0.001 ） at 0 - 1 h, 0.55 （95%CI 0.43 ~ 0.71, P 〈 0.001 ） at 4 h and 0.48 （95%CI 0.34 to 0.66, P 〈 0.001 ） at 24 h after surgery. No major complications related to topical ketamine were observed. Conclusions For the patients receiving general anesthesia and endotracheal intubation, topical prophylactic application of ketamine can significantly reduce the incidence of POST without major complications.
出处
《实用医学杂志》
CAS
北大核心
2014年第11期1826-1829,共4页
The Journal of Practical Medicine
关键词
术后咽喉痛
气管内插管
氯胺酮
META分析
Postoperative sore throat
Endotracheal intubation
Ketamine
Meta-analysis.
