摘要
microRNA （ miRNA）是真核生物中广泛存在的一类长21～23个核苷酸的非编码RNA分子，通过与靶基因mRNA的特异结合调节基因转录后表达，在调控细胞周期、生物体发育时序等方面起重要作用。 miR160、miR167和miR3903个miRNAs家族均为靶向ARF（ Auxin Response Factor）基因家族，预示着它们在行使调控功能的过程中既有相似性又有特异性。笔者详细阐述了miR160/miR167/miR390在植物发育过程中的调控作用及与其靶基因之间的相互调控关系，发现 miR160/miR167/miR390均在植物生长发育过程中发挥重要的作用，但miR160则侧重于调控胚胎和根的发育，miR167侧重于调控植物花和果实的发育，而miR390则对植物横向器官的发育具有调控作用，并且，miR160/miR167/miR390与其靶基因之间存在反馈调节作用。
MicroRNA （ miRNA） is endogenous and non-coding small RNA with 21-23 nucleotides, and it widely exits in eukaryotes. MiRNAs repress gene expression at post transcriptional level by acting on near-perfect complementary se-quences in mRNA coding region to guide cleavage and translational repression, and it plays an important role in regula-ting cell cycle and development timing of biology. Three miRNA families including miR160, miR167 and miR390 all tar-geting to ARF （ Auxin response factor） gene family have been reviewed, and which indicates that they fulfil the similar and differential function. For example, miR160/miR167/miR390 plays an important role in plant development. But miR160 focuses on regulating embryo and root development, miR167 focuses on the regulation of flowers and fruit devel-opment, and miR390 has remarkable effect on regulating plant lateral organ development. Moreover, feedback regulation exists between miR160/miR167/miR390 and their target genes.
出处
《南京林业大学学报（自然科学版）》
CAS
CSCD
北大核心
2014年第3期155-159,共5页
Journal of Nanjing Forestry University：Natural Sciences Edition
基金
国家自然科学基金项目(31100484)
江苏省高校自然科学研究重大项目(13KJA220002)
国家高技术研究发展计划(2013AA102703)
