摘要
目的探讨巴曲酶对突发性耳聋患者凝血及纤维蛋白溶解功能的影响。方法选择突发性耳聋患者87例,在巴曲酶治疗前及治疗3、6d后检测患者凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)、D-二聚体及纤维蛋白(原)降解产物(FDP)。结果与治疗前比较,经巴曲霉治疗后,患者PT、TT延长(P<0.05),Fib降低(P<0.01),FDP升高(P<0.01),而APTT、D-二聚体的差异无统计学意义(P>0.05)。结论 PT、TT、Fib、FDP可用于巴曲酶治疗突发性耳聋患者凝血及纤维蛋白溶解功能的监测。
Objective To investigate the effects of batroxobin on blood coagulation and fibrinolytic function of patients with sud-den deafness .Methods 87 patients with sudden deafness were enrolled .Their prothrombin time（PT ） ,activated partial thrombo-plastin time（APTT） ,thrombin time（TT） ,fibrinogen（Fib） ,D-dimer and fibrin/fibrinogen degradation products（FDP） were detec-ted before batroxobin treatment and 3 ,6 days after treatment .Results Compared with pre-treatment ,patients after treatment expe-rienced prolonged PT and TT （P〈0 .05） ,decreased Fib（P〈0 .01） ,increased FDP （P〈0 .01） ,and the difference of APTT ,D-di-mer between treatment before and after showed no statistically significant （P〉0 .05） .Conclusion PT ,TT ,Fib ,FDP can be applied to monitor the coagulation and fibrinolytic function of patients with sudden deafness treated with batroxobin .
出处
《国际检验医学杂志》
CAS
2014年第10期1268-1269,共2页
International Journal of Laboratory Medicine
