摘要
[目的]研究稳定型心绞痛(stable angina,SA)与不稳定型心绞痛(unstable angina,UA)患者血清单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)与同型半胱氨酸(homocysteine,HCY)浓度的差异,以确定其对心绞痛的临床意义。[方法]选取2011年3月至2013年3月间在我院诊治的UA患者67例与SA患者65例,以年龄相仿的正常人群60例为对照组。UA组末次心绞痛发作12 h内采集静脉血,SA组和对照组于清晨采集静脉血,ELISA法检测血清MCP-1和HCY。[结果]各组间血清MCP-1与HCY水平间差异有统计学意义(P<0.05),其中UA组和SA组患者的两者水平高于对照组,差异有统计学意义(P<0.05),UA组患者血清MCP-1与HCY水平高于SA组,差异有统计学意义(P<0.05)。[结论]心绞痛患者血清炎症因子MCP-1和HCY高于健康人,UA患者高于SA患者,检测炎症因子MCP-1和HCY水平有助于鉴别和筛选高危的心绞痛患者。
[Objective] To study the difference between stable angina（SA） and unstable angina（UA） on monocyte chemoattractant protein-1（MCP-1）and homocysteine（HCY）concentrations, to define its clinical meaning to angina. [Method] Select 67 cases of UA and 65 cases of SA, take 60 normal persons of similar age as healthy control group; col ect the vein blood within 12h at the last attack of UA group, col ect the vein blood in early morning for SA group and control one; measure serum MCP-1 and HCY with ELISA method. [Result] The MCP-1 and HCY levels had difference among al groups, among which, groups UA and SA were higher than control one, with difference of statistical meaning; while UA group was higher than SA group, with difference of statistical meaning. [Conclusion] In angina patients, the serum inflammatory factors MCP-1 and HCY levels are higher than healthy persons, UA higher than SA patients;to test MCP-1 and HCY levels is helpful to identifying and screening high-risk angina patients.
出处
《浙江中医药大学学报》
CAS
2014年第3期306-308,共3页
Journal of Zhejiang Chinese Medical University
