摘要
目的探讨维生素D受体(VDR)等位基因多态性与肺腺癌易感性的关系。方法 172例河北汉族肺腺癌患者和180例健康对照。采用聚合酶链反应-限制性片段长度多态性的方法对VDR的Bsm1、Fok1等位基因多态性与肺腺癌的关系进行研究。结果肺腺癌组VDR基因Bsm1位点基因型分布、等位基因分布Fok1位点基因型分布与健康对照组比较差异有统计学意义(χ2值分别为8.111和6.492,P<0.05)。Fok1位点基因型分布,其等位基因分布与健康对照组比较差异无统计学意义(P>0.05)。结论 VDR基因Bsm1位点多态性与肺腺癌发病风险相关联。Bsm1位点B等位基因可能增加肺腺癌的发病风险。VDR基因Fok1位点多态性与肺腺癌发病风险可能关联。
Objective To explore the correlation between gene polymorphisms of vitamin D receptor （ VDR） and susceptibility of lung adenocarcinoma .Methods The 172 patients with lung adenocarcinoma （ lung adenocarcinoma group ） and 180 healthy subjects （control group） were enrolled in the study,and all the subjects were Chinese Han people in Hebei province.The correlation between allele polymorphism of Bsm 1,Fok1 site of VDR and lung adenocarcinoma was analyzed by polymerase chain reaction-restriction fragment length polymorphism method .Results There were significant differences in genotype distribution and Bsm 1 genotype distribution of VDR gene between lung adenocarcinoma group and control group （χ2=8.111 and 6.492, P 〈0.05）.However there were no significant differences in genotype distribution and Bsm 1 genotype distribution of VDR gene between lung adenocarcinoma group and control group （ P 〉0.05）.Conclusion Bsm1 gene site polymorphism of VDR gene is closely correlated to pathogenesis risk of advanced lung adenocarcinoma .Bsm1 B allele may increase the pathogenesis risk of lung cancer .Fok1 site polymorphism of VDR may be related with pathogenesis risk of lung cancer.
出处
《河北医药》
CAS
2014年第12期1780-1782,共3页
Hebei Medical Journal
关键词
多态性
维生素D
肺肿瘤
易感性
polymorphisms
vitamin D
lung neoplasms
susceptibility
