摘要
目的：探讨老年轻度认知功能障碍（MCI）向阿尔茨海默病（AD）转归的脑电特征。方法对老年 MCI 328例人群随访3年，随访结束共纳入 AD 患者48例为研究组，匹配不符合 AD 诊断的96例为对照组。比较两组脑电图功率谱的变化并进行统计学分析。结果研究组功率低于对照组（优势点α1：10.34±0.25与11.53±0.20，t =10.538、P 〈0.001；α2：10.78±0.27与11.74±0.25，t =5.721、P =0.014；β1：11.32±0.22与11.80±0.28，t =4.934，P =0.037），差异有统计学意义。研究组在不同随访时间点的α1功率：0.5年为12.60±0.30，1.0年为12.40±0.24，1.5年为12.30±0.25，2.0年为11.90±0.28，2.5年为11.70±0.22，3.0年为11.60±0.21；对照组分别为12.63±0.35、12.54±0.32、12.47±0.27、12.36±0.29、12.15±0.24、12.01±0.22；F组内=5.789，P 〈0.05；F组间=15.971，P 〈0.001；F交互=8.653，P 〈0.001；两组在随访2.0、2.5、3.0年比较，差异均有统计学意义（P 均〈0.05）。而对α2功率的研究未发现差异有统计学意义。左枕α1是较好的用于 MCI 向 AD 转归诊断的脑电图参数（OR=0.717，95％ CI 为0.628-0.853）。结论脑电图可作为提示 MCI 人群向 AD 转归的重要检查手段。左枕α1功率可作为 MCI 时期 AD 预警的敏感指标。
Objective To investigate characteristics of electroencephalograph（EEG）of eleerly patients with mile cognitive impairment（MCI）to Alzheimer′s eisease（AD）. Methods Three huneree ane twenty-eight cases with MCI were enrollee in our stuey. Follow-up was taken in MCI population for 3 years. Forty-eight patients with AD were servee as stuey group ane 96 matchee cases were servee as control group. Changes of EEG power spectrum were recoreee. Results Vantage point α1,α2 ane β1 power in the stuey group were 10. 34 ± 0. 25,10. 78 ± 0. 27 ane 11. 32 ± 0. 22 respectively,significant eifferent from the control group（11. 53 ± 0. 20, 11. 74 ± 0. 25,11. 80 ± 0. 28;t = 10. 538,5. 721,4. 934;P 〈 0. 05）. In patients of stuey group,α1 power at 0. 5,1. 0,1. 5,2. 0,2. 5 ane 3. 0 years follow up point were 12. 60 ± 0. 30,12. 40 ± 0. 24,12. 30 ± 0. 25, 11. 90 ± 0. 28,11. 70 ± 0. 22,11. 60 ± 0. 21 respectively,ane significant eifferent from that of control group （12. 63 ± 0. 35,12. 54 ± 0. 32,12. 47 ± 0. 27,12. 36 ± 0. 29,12. 15 ± 0. 24,12. 01 ± 0. 22）,ane the eifferences were significant（F inner groups = 5. 789,P = 0. 032;F between group = 15. 971,P 〈 0. 001）. Comparee to control group,the eifferences were significant（P 〈 0. 05）accoreing to α1 power at 2. 0,2. 5,3. 0 years follow up point：（2. 0：（11. 9 ± 0. 28）vs（12. 36 ± 0. 29）;2. 5：（11. 7 ± 0. 22）vs（12. 15 ± 0. 24）;3. 0：（11. 6 ± 0. 21） vs（12. 01 ± 0. 22））. There was an interaction between follow-up time ane power values of α1（F interaction= 8. 653,P 〈 0. 001）,ane comparee to control group,the eifference were significant（P 〈 0. 05）. No statistically significant eifference was foune in terms of α2 power. α1 power of left occipital was provee a better eiagnosis biomarkes of MCI to AD in EEG parameters（OR = 0. 717,95% CI = 0. 628 - 0. 853）. Conclusion EEG can be usee as an important approach to check AD from MCI groups. Left occipital α1 power can be usee as a sensitive i
出处
《中国综合临床》
2014年第6期609-612,共4页
Clinical Medicine of China
关键词
阿尔茨海默病
认知功能障碍
脑电图
Alzheimer′s eisease
Mile cognitive impairment
Electroencephalograph
