摘要
目的：探讨血尿酸（SUA）水平对男性人群全因死亡的影响。方法采取前瞻性队列研究方法，以2006-2007年度参加开滦集团健康体检的81110名男性职工为研究对象，排除既往有心肌梗死、脑卒中、恶性肿瘤病史及肾小球滤过率（eGFR）＜30 ml/（min·1.73 m2）、服用对SUA有影响的药物者；进行统一问卷调查、血液生化检查，平均随访（47.5±4.3）个月，依据2006-2007年度SUA值将研究对象五等分，采用Cox比例风险模型分析SUA对男性人群全因死亡的影响。结果（1）至2010-2011年度随访结束，不同SUA五分位组死亡例数分别为315、278、243、292、341，对应全因死亡率分别为2.43%、2.36%、1.96%、2.42%、2.92%。（2）单因素Cox比例风险回归模型分析显示，以SUA第三分位组为参照，第一、二、四、五分位组发生全因死亡的HR值（95%CI）分别为1.32（1.11～1.56）、1.19（1.00～1.41）、1.20（1.01～1.43）、1.41（1.19～1.66）。（3）多因素Cox比例风险回归模型分析显示，校正年龄、SBP、DBP、BMI、TG、TC、HDL-C、LDL-C、FPG、高敏C反应蛋白、吸烟史、饮酒史、文化程度、职业、经济收入后，以SUA第三分位组为参照，第一、二、四、五分位组发生全因死亡的HR值（95%CI）分别为1.26（1.06～1.51）、1.20（1.01～1.44）、1.25（1.05～1.49）、1.42（1.19～1.68）。结论 SUA为全因死亡的独立危险因素，该值过高或过低都将增加全因死亡的发病风险，其五分位组全因死亡率呈“U”形曲线。
Objective To explore the association between serum uric acid （SUA） and all-cause mortality in men. Methods In this prospective cohort study,data being used was derived from the Kailuan study cohort. A total of 81 110 male workers who had taken part in the Kailuan physical examination were enrolled. Subjects with previous myocardial infarction,stroke,cancer, eGFR〈30 ml/（min·1.73 m2）accidental deaths and those ever used drugs that seemed to have showed an effect on blood uric acid,were excluded. All the information was gathered from a unified questionnaire,measured by blood biochemistry and with the mean period of follow up as（47.5±4.3） months. Based on the 2006-2007 SUA value,observed objects were divided into five groups,with multivariate Cox proportional hazard regression analysis used to estimate the relationship between SUA and all-cause mortality in men. Results 1）At the end of the follow-up period in 2010-2011, the number of deaths were 315,278,243,292 and 341 among the different SUA quinte,with incidence rates of all-cause mortality as 2.43%,2.36%,1.96%,2.42%and 2.92%,respectively. 2）Data from the Single factor Cox proportional hazard regression analysis showed that,when comparing with the third quinte,HR values of the all-cause mortality were 1.32（1.11-1.56）,1.19（1.00-1.41）,1.20（1.01-1.43）and 1.41（1.19-1.66）in other four groups,respectively. 3）When factors were adjusted for age, systolic blood pressure,diastolic blood pressure,body mass index,triglyceride,total cholesterol, high-density lipoprotein cholesterol, low density lipoprotein cholesterol, fasting glucose, high-sensitivity C-reactive protein,smoking history and history of drinking,education,profession, economy,etc.,results from the Multiple Cox proportional hazard regression analysis showed the HR values of the all-cause mortality were 1.26（1.06-1.51）,1.20（1.01-1.44）,1.25（1.05-1.49）,1.42 （1.19-1.68） in other four groups,respectively,comparing to the third quinte. Conclusion Using SUA as the inde
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2014年第6期650-654,共5页
Chinese Journal of Epidemiology
关键词
血尿酸
全因死亡
Serum uric acid
All-cause mortality
