摘要
目的观察静脉泵入不同襻利尿剂和给药速度对急性心力衰竭伴水肿患者肾功能及尿酸(UA)的影响。方法将急性心力衰竭伴水肿患者99例随机分为呋塞米长时程组、呋塞米短时程组和托拉塞米组,每天静脉泵入等效剂量的襻利尿剂,观察血肌酐(SCr)、尿素(Urea)和UA的变化。结果 3组间不同时间的Urea比较差异无统计学意义(P均>0.05)。治疗第4天和第7天,呋塞米长时程组和呋塞米短时程组SCr和UA水平均低于托拉塞米组(P均<0.05),呋塞米长时程组和呋塞米短时程组间比较差异无统计学意义(P均>0.05)。结论襻利尿剂经静脉泵入治疗急性心力衰竭伴水肿,未对肾功能和UA产生明显影响;呋塞米和托拉塞米对SCr和UA的影响存在一定差异。
Objective It is to observe the effects of different loop diuretics and different drug delivery rate by intravenous pump on renal function and uric acid （UA） in the patients with acute heart failure and edema. Methods 99 patients with acute heart failure and edema were randomly divided into furosemide in long-time group, furosemide in short-time group and to- rasemide group treated daily by intravenous pump equivalent dosages of loop diuretics, the changes of serum ereatinine （SCr） , urea and UA were observed. Results There was no significant difference in urea at different time among the three groups（P 〉 0.05）. On the fourth day and senventh day of treatment, the levels of SCr and UA in furosemide groups of long time and short time both were lower than that in torasemide group（P 〉 0.05 ） , but there was no significant difference in the levels between the two furosemide groups（ P 〉 0.05 ）. Conclusion Loop diuretics by intravenous pump has no obvious effect on renal function and UA in the treatment of acute heart failure with edema, but there were some differences in the effects on SCr and UA between furosemide and torasemide.
出处
《现代中西医结合杂志》
CAS
2014年第17期1831-1832,1835,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
河北省卫生厅青年科技课题(20110600)
关键词
急性心力衰竭
襻利尿剂
静脉泵入
肾脏功能
尿酸
acute heart failure
loop diuretics
pump into vein
renal function
uric acid
