摘要
目的探讨肿瘤坏死因子-α（TNF-α）、内毒素（LPS）、白细胞介素-6（IL-6）在重症颅脑损伤急性肝损伤发生过程中的相关性。方法收集2009年1月～2012年6月在笔者医院急诊科就诊，创伤指数（TI）≥17分、格拉斯哥昏迷评分（GCS）≤10分，除外合并其他部位损伤及在急诊死亡的重症颅脑损伤患者65例，急诊救治的同时抽血检查谷丙转氨酶（A1月）、谷草转氨酶（AST）、TNF-α、LPS、IL-6，与正常对照组相比较，并对观察组病例的检验结果进行相关性分析。结果观察组肝功能检验结果：ALT279．43±41．35U／L，AST258．49±39．62U／L；损伤因子检验结果：TNF-α 39．93±18．88ng／ml，LPS479．38±91．48IU／L，IL-6469．61±73．66ng／ml。与对照组同类数据相比，差异均有统计学意义（P均〈0．001）。观察组ALT与TNF-α、LPS、IL-6比较，其相关系数（r）均〉0．8552，AST与TNF-α、LPS、IL-6比较，r均〉0．8574，差异均有统计学意义，均呈显著正相关。结论TNF-α、LPS、IL-6参与了重症颅脑损伤急性肝损伤的发生、发展。在急诊救治重症颅脑损伤时，早期的加强对TNF-α、LPS、IL-6的干预，则有可能减轻急性肝损伤的程度。
Objective To investigate the correlation between tumor necrosis factor -α （ TNF -α）, lipopolysaccharide （ LPS ） , inter- leukin - 6 （ IL - 6） with acute liver functional lesion in severe craniocerebral injury. Methods 65 subjects with severe craniocerebral inju- ry were collected in the 253tb Hospital of PLA from January in 2009 to June in 2012, of whom the trauma index were all above or equal to 17 points,glasgow coma scale low or equal to 10 points. They were examined alanine aminotransferase（ALT） ,aspartate aminotransferase （AST） , TNF -α,LPS,IL - 6 for correlative analysis while they were emergency treated at the same time. Results The liver function of the observe group examined results ALT 279.43 ± 41.35U/L,AST 258.49 ±39.62U/L. The injury factors examined results were TNF-α 39.93 ±18.88ng/ml,LPS 479.38 ± 91.48IU/L,IL -6 469.61 ± 73.66ng/ml. They both had evidently difference between the control group and the observe group and had obviously correlation between the liver function and the injury factors of the observe group. Conclu. sion TNF -α,LPS and IL - 6 all participate in the process of the acute liver functional lesion in severe craniocerebral injury. The incho- ate interference and treatment against TNF -α, LPS, IL - 6 are possible to improve the liver functional lesion in severe craniocerebral injury.
出处
《医学研究杂志》
2014年第5期115-118,共4页
Journal of Medical Research
关键词
重症颅脑损伤
急性肝损伤
肿瘤坏死因子
内毒素
白细胞介素-6
Severe craniocerebral injury
Acute liver functional lesion
Tumor necrosis factor -α
Lipopolysaccharide
Interleukin - 6
