摘要
目的了解碘造影剂不良反应的发生率及其相关因素,探索药品上市后不良反应再评价的方法。方法收集、整理、分析有关碘造影剂的不良反应的临床研究、不良反应监测及案例报道,包括个案和经典案例分析。结果本研究纳入9 012例碘造影剂不良反应(ADR);原发疾病为循环系统的患者、老年患者及有其他药物过敏史的患者更容易发生ADR;ADR多发生在30min内;根据发表资料尚无法鉴别ADR。结论当前的证据表明,碘造影剂的ADR高,临床使用应密切关注,防止给患者带来不必要的伤害。
Objective To find out the occurrence rate of adverse drug reaction （ADR） following iodine-contrast media and to under-stand the relative factors causing ADR ,to preliminarily explore the methods for re-evaluation of the drug after marketing .Method The literature was classified into 3 categorise ,i .e .synchronous clinical study ,ADR monitoring and medical records analysis ,as well as individual or typical case reports .Results Totally 9 012 cases were included in this review .Although we are unable to an-swer the question weather the incidence of adverse drug reaction （ADR） induced by iodine-contrast media due to the absence of to-tal amount of production and market information ,it was estimated based on the limited data that the possibility of ADR should be high .The review showed that the ADR was easier to occur in 30 min after injecting into the older and the one who had circulation system disease or drug allergy .Conclusion Current evidence shows that iodine-contrast media has a high risk of ADR .We should pay close attention to the application of iodine-contrast media to prevent unnecessary harmness .
出处
《西北药学杂志》
CAS
2014年第3期290-292,共3页
Northwest Pharmaceutical Journal
基金
新疆医科大学2012年度科研创新基金项目(编号XJ2012121)
关键词
碘造影剂
不良反应
系统评价
iodine-contrast media
systematic evaluation
