摘要
目的：探讨头孢哌酮/舒巴坦治疗急诊重症感染患者的临床疗效。方法根据患者入院前30 d是否服用抗生素药物分为观察组和对照组。两组均给予头孢哌酮/舒巴坦治疗，每日2次，每次4.0 g。比较两组疗效及细菌清除率。同时对分离菌株进行药敏试验，并记录不良反应。结果观察组和对照组治疗有效率分别为84.62%和82.05%，细菌清除率分别为88.2%（30/34）、81.1%（30/37），两组在疗效和细菌清除率方面比较差异无统计学意义（ P 〉0.05）。头孢哌酮/舒巴坦治疗重症感染的总有效率为83.33%，细菌清除率为84.5%（60/71）。患者分离菌对亚胺培南/西司他丁钠、头孢哌酮/舒巴坦、头孢哌酮钠的敏感率分别为86.67%（39/45）、93.33%（42/45）、64.44%（29/45）。头孢哌酮/舒巴坦的敏感率与亚胺培南/西司他丁钠比较差异无统计学意义（ P 〉0.05），与头孢哌酮钠的敏感率比较差异有统计学意义（ P 〈0.05）。本研究患者无严重不良反应发生。结论头孢哌酮/舒巴坦在治疗重症感染患者中具有较强的临床疗效，值得在临床中做为经验用药予以普及和推广。
Objective To investigate the clinical efficacy of cefoperazone / sulbactam on patients with severe infections. Methods Patients were divided into observation group and control group accord-ing to whether taking antibiotics drugs during 30 days before admission. Both groups were given cefopera-zone / sulbactam therapy,2 times a day,4. 0 g per time. The clinical efficacy and bacterial clearance rates of the two groups were compared. While the isolates were given susceptibility testing and the adverse reactions were recorded. Results The effective rate in treatment group and control group was 84. 62% and 82. 05% ,retrospectively. The bacterial clearance rate was 88. 2% （ 30 / 34 ）and 81. 1%（30 / 37）,there was no significant difference in terms of efficacy and bacterial clearance rate between the two groups（ P 〉0. 05）. Cefoperazone / sulbactam in the treatment of severe infections, the total effective rate was 83. 33 % ,the bacterial clearance rate was 84. 5%（60 / 71）. The sensi-tivity rate of isolates to imipenem / cilastatin sodium,cefoperazone / sulbactam and cefoperazone sodi-um was 86. 67%（39 / 45）,93. 33%（42 / 45）,64. 44%（29 / 45）. The sensitivity rate had no significant difference between the cefoperazone / sulbactam and imipenem / cilastatin sodium（ P ＆gt;0. 05）,but had significant difference between the cefoperazone / sulbactam and cefoperazone sodium （ P 〈 0. 05）. The patients had no serious adverse reactions. Conclusions There is good clinical ef-ficacy of cefoperazone / sulbactam on patients with severe infections,and it is worth to be popularized in clinical medicine as experience.
出处
《中国实用医刊》
2014年第12期20-22,共3页
Chinese Journal of Practical Medicine
关键词
重症感染
头孢哌酮
舒巴坦
急诊
药敏试验
Severe infection
Cefoperazone / sulbactam
Emergency
Susceptibility testing
