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Rhupus综合征12例临床分析

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摘要 目的:探讨类风湿关节炎(RA)和系统性红斑狼疮(SLE)重叠综合征(Rhupus综合征)临床特点及诊断和治疗方法,以提高对Rhupus综合征的认识。方法:对确诊的12例Rhupus综合征患者的临床表现、血清学指标、影像学检查以及诊治情况进行回顾性分析。结果:12例Rhupus综合征患者男女比例1∶11,起病年龄23-48岁。10例患者以RA为首发表现;出现关节肿痛12例,晨僵10例,血液系统损害10例;类风湿因子定量增高9例,抗环瓜氨酸肽抗体定量增高7例,抗Sm抗体阳性8例;12例患者均发现抗核抗体阳性、红细胞沉降率及C反应蛋白增高、免疫球蛋白增高,补体下降及双手影像学改变。12例患者均采用糖皮质激素联合改善病情抗风湿药物治疗(DMARDs),病情得到有效缓解。结论:Rhupus综合征以中年女性多发,临床表现较单纯RA及SLE更为复杂,同时兼有RA及SLE临床特点,但多以RA起病常见,关节症状较重,SLE表现相对较轻,可有脏器损害,可同时或先后出现RA和SLE血清学指标,采用糖皮质激素联合DMARDs治疗能有效缓解病情。
出处 《蚌埠医学院学报》 CAS 2014年第5期624-626,共3页 Journal of Bengbu Medical College
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参考文献13

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