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肝细胞肝癌组织中p21活化蛋白激酶6的表达及意义 被引量：1

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摘要 目的观察肝细胞肝癌(HCC)组织中p21活化蛋白激酶6(PAK6)的表达,并探讨其意义。方法采用Western blot技术检测8例新鲜HCC及相应癌旁组织中PAK6的表达情况;采用免疫组化SP方法检测121例HCC及癌旁组织石蜡切片中PAK6的表达情况,分析HCC组织中PAK6蛋白表达与临床病理参数的关系。结果 Western blot结果显示,HCC组织中PAK6表达均显著高于癌旁组织。免疫组化结果显示,PAK6在HCC组织中高表达,在相应癌旁组织中表达相对较低或缺失(P<0.01);HCC组织中PAK6蛋白高表达与肿瘤的Edmondson-steiner分级(P=0.006)、结节数目(P<0.01)有关,与患者的年龄、性别、肿瘤大小及有无转移、血清HBsAg是否阳性、是否伴有肝硬化、血清AFP水平不相关(P均>0.05)。结论 HCC组织中PAK6呈高表达,PAK6高表达可能与HCC的发生、发展有关。
作者 陈宏伟 王春华 李军良 朱勇 王建新 吴侠
机构地区 秦皇岛市第一医院
出处 《山东医药》 CAS 2014年第20期65-67,F0003,共4页 Shandong Medical Journal
基金 河北省秦皇岛市科学技术研究与发展计划项目(201302A073)
关键词 肝细胞肝癌 p21活化蛋白激酶6 免疫印迹 免疫组织化学
分类号 R735.7 [医药卫生—肿瘤]
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参考文献15

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二级参考文献12

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山东医药
2014年 第20期

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