摘要
目的研究非肥胖2型糖尿病合并非酒精性脂肪性肝病危险因素及与并发症的相关性。方法选择428例非肥胖2型糖尿病患者,分为非酒精性脂肪性肝病组(NAFLD组)193例和非NAFLD组235例,对比两组生活指标、物理指标、一般资料及慢性并发症发生率,分析2型糖尿病合并NAFLD的危险因素。结果 NAFLD组外周血HbA1C、FINS、C肽、HOMA-IR、TC、TG、LDL-C、ALT、AST、UA水平均显著高于非NAFLD组(P<0.05),AST/ALT比值显著低于非NAFLD组(P<0.05)。NAFLD组BMI、腰臀比显著高于非NAFLD组(P<0.05)。其中HOMA-IR、TG、LDL-C、腰臀比是2型糖尿病合并非酒精性脂肪性肝病的危险因素(P<0.05)。NAFLD组糖尿病肾病、高血压、动脉粥样硬化、冠心病、脑血管病变的发生率显著高于非NAFLD组(P<0.05)。结论胰岛素抵抗、血脂异常及体脂分布不均与非肥胖2型糖尿病患者合并NAFLD有关,合并NAFLD的患者血管病变发生率升高。
Objective To study the risk factors and complications of non-obese type 2 diabetes mellitus with nonalco-holic fatty liver disease. Methods A total of 428 cases of non-obese type 2 diabetic patients were divided into groups of non-alcoholic fatty liver disease （NAFLD group） of 193 cases and non-NAFLD group of 235 cases, compare living index, physical indicators, general information and chronic complications rate of type 2 diabetes risk factors for NAFLD of two groups. Results NAFLD peripheral blood HbA1C, FINS, C peptide, HOMA-IR, TC, TG, LDL-C, ALT, AST, UA levels were significantly higher than non-NAFLD group （P 〈0.05）, AST/ALT ratio were significantly lower in non-NAFLD group （P〈0.05）. NAFLD group BMI, waist-hip ratio were significantly higher than non-NAFLD group （P 〈0.05）. Included HOMA-IR, TG, LDL-C, waist-hip ratio were type 2 diabetes mellitus with nonalcoholic fatty liver disease risk factors （P 〈0.05）. NAFLD group diabetic nephropathy,hypertension,atherosclerosis,coronary heart disease, cerebrovascular disease incidence were significantly higher than non-NAFLD group（P 〈0.05）. Conclu-sion Insulin resistance, dyslipidemia and fat maldistribution and non-obese type 2 diabetic patients with NAFLD re-lated chronic complications in patients with NAFLD increased incidence.
出处
《中国现代医生》
2014年第14期12-15,共4页
China Modern Doctor
基金
国家自然科学基金(81000064/H0203)
关键词
2型糖尿病
非酒精性脂肪性肝病
危险因素
并发症
慢性
胰岛素抵抗
Type 2 diabetes
Non-alcoholic fatty liver disease
Risk factors
Complications
Chronic
Insulin resis-tance
