摘要
目的:全面检索附子-瓜蒌临床同用的随机对照试验研究文献,分析探讨附子-瓜蒌反药同用的临床研究文献特征。方法:检索中国期刊全文数据库、中文科技期刊全文数据库、中文生物学期刊数据库、中国生物医学数据库、万方数据库、中国中医药在线、PubMed、Cochrane Library数据库中应用附子-瓜蒌临床同用治疗疾病的随机对照试验研究文献,提取文献中报告的文献特征。结果:共检索出符合要求的57篇附子-瓜蒌临床同用随机对照试验研究文献,临床上附子-瓜蒌反药组合同用时,附子多以"制附子"入药,瓜蒌则多以生品入药;两者临床组合同用多以1∶1的比例配伍使用,多制成"汤剂","内服(口服)"使用;附子"温助心肾之阳"的功效被提及的频率最高,而瓜蒌"宽胸利气"的功效被提及的频率最多。结论:临床上确实存在附子-瓜蒌反药组合同用的文献,但这些临床文献研究之间异质性过高,无法进行定量综合分析,因而研究结果只适用于所检索到的有限的临床研究文献,至于临床上附子-瓜蒌反药组合是否能安全、有效、合理应用,还需要经过大量的理论、实验与临床等多方面的更加深入的研究探索。
Objective： To approach the applied condition of Aconiti Lateralis Radix Praeparate and Trichosanthis Fructus using together in clinical. Method： According to zhe special search condition to search the clinical literature of Aconiti Lateralis Radix Praeparate and Trichosanthis Fructus using together, then to analyze these literature from the dosage, the compatibility proportion, the dosage forms, the administration route and the processing drug conditions. Result： Altogether we have retrieved 57 satisfactory research documents on randomized controlled clinical trial of simultaneous use of monkshood and snakegourd fruit. In the combined use of the herbs with contrary natures, however, the monkshood is usually fire-grilled while the snakegourd fruit is often used in raw. In most cases, the 2 herbs are made in decoction for drink with the proportion of 1 ： 1. For monkshood, the function of ＇ mild recuperation of heart and kidney Yang＇ is mentioned the most, and for snakegourd fruit, ＇ regulating the flow of Qi and relieving depression in the chest＇ the most. Conclusion： The literatures show that Aconiti Lateralis Radix Praeparate and Trichosanthis Fructus could be used together in clinic treatment. As a result, it was impossible to evaluate clinical effects. What＇s more the research was lack of adverse incidents report and theory about imcompatible herbs using together. If we want to recognition this combination＇ safety and effectiveness, we still need time to do more research.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第11期218-222,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重点基础研究发展计划(973计划)项目(2011CB505300
2011CB505306)
国家教育部新世纪优秀人才支持计划项目(NCET-10-0271)
关键词
附子
瓜蒌
随机对照试验研究
Aconiti Lateralis Radix Praeparate
Trichosanthis Fructus
randomized controlled trial study
