摘要
目的:观察传统三联疗法根除幽门螺杆菌与联合维生素C、维生素E三联疗法根除幽门螺杆菌之间的差异。方法:将120例患者随机分成A、B两组,A组采用埃索美拉唑镁40 mg qd+克林霉素500mg bid+阿莫西林1 000 mg bid+维生素E200 mg bid+维生素C500 mg bid;B组采用埃索美拉唑镁40 mg qd+克林霉素500 mg bid+阿莫西林1 000 mg bid。两组均治疗7 d。停药1月后复查14C-尿素呼气试验,确定Hp根除情况。结果:经ITT分析,A、B两组幽门螺杆菌清除率分别为87.9%和81.4%,两组比较差异无统计学意义(P>0.05)。经PP分析,A、B两组幽门螺杆菌清除率分别为85.0%和80.0%,组间差异无统计学意义(P>0.05)。结论:维生素C、维生素E联合三联疗法根除幽门螺杆菌率高于传统三联疗法根除幽门螺杆菌率,但两者之间差异无统计学意义。
Objective：To observe the discrepancy between standard triple therapy and standard triple therapy plus vitamins E and C in eradication of Helicobacter pylori（ H. pylori）. Methods ：120 patients were enrolled into our study and were divided into two groups randomly. Patients in group A were treated with Esomeprazole Magnesium（40 mg,q. i. d） ,Clindamycin（500 mg,b. i. d. ） ,Amoxicillin （1 000 mg,b. i. d. ） ,vitamin C（500 mg,b. i. d. ）and vitamin E（200,b. i. d. ） ,while patients in groups B received Esomeprazole Mag nesium（40 mg,q. i. d. ）,Clindamycin（500 mg,b. i. d. ）and Amoxicillin（ 1 000 mg,b. i. d. ）. All patients received therapy for seven days. One month later all patients underwent ^14 C-urea breath test to determine the eradication rate of H. pylori. Results ： By intention-to treat analysis,the eradication rate of H. pylori in group A and group B were 87.9% and 81.4% ,respectively. There is no obvious differ ence（ P 〉 0. 05）. By per-protocol analysis,the eradication rate of H. pylori in group A and group B were 85.0% and 80.0% , respec tively. However,no significant difference was observed. Conclusion：The higher eradication rate of H. pylori was observed in patients treated with vitamins E and C plus standard triple therapy compared with standard triple therapy alone,however,no significant difference was observed between these two treatments.
出处
《川北医学院学报》
CAS
2014年第2期147-149,共3页
Journal of North Sichuan Medical College
基金
四川省卫生厅科研项目(100333)
