摘要
原发性胆汁性肝硬化(PBC)以肝内小胆管的损伤为特征,但其损伤机制尤其是B细胞免疫在其中发挥的作用尚不明确。从B细胞和浆细胞在PBC肝组织中的分布、B细胞清除、PBC血清中异常增高的IgM产生机制及其组织器官来源、线粒体抗体的产生机制以及在胆管损伤中的可能作用、PBC中特征性的自身抗体等方面,回顾了B细胞免疫在PBC发病机制中的可能作用。通过以上分析,认为B细胞免疫的确在PBC的发病机制中发挥了重要作用,但仍有很多关键的问题尚未得到阐明。
Primary biliary cirrhosis （PBC）is characterized by injury of small intrahepatic bile ducts,but its mechanism,especially the role of B cell immunity in this disease,remains unclear.The possible role of B cell immunity in the pathogenesis of PBC is reviewed from the following aspects：distribution of B cells and plasma cells in the liver tissues of PBC patients,clearance of B cells,mechanism of abnormal increase in serum IgM and its sources among PBC patients,mechanism of production of antimitochondrial antibodies and their possible functions in bile duct injury,and typical autoantibodies in PBC.B cell immunity is considered to play a significant role in the pathogenesis of PBC,but there are still many key problems to be clarified.
出处
《临床肝胆病杂志》
CAS
2014年第5期400-404,共5页
Journal of Clinical Hepatology
基金
首都卫生发展专项基金(2011-2018-05)
关键词
肝硬化
胆汁性
免疫
体液
B淋巴细胞
综述
liver cirrhosis,biliary
immunity,humoral
B lymphocytes
review
