摘要
目的探讨羊水细胞培养和染色体核型分析在产前诊断中的的应用价值。方法对1 016例孕中期孕妇,在B型超声波检查的监护下行羊膜腔穿刺术,对抽出的羊水进行细胞培养及染色体核型分析。结果 1 016例孕妇中,一次性羊水穿刺、细胞培养成功1 011例(99.5%)。胎儿染色体异常核型检出率为10.3%(105/1 016),其中,结构异常8.3%(85/1 016);数目异常2.0%(20/1 016)。856例接受随访。结论羊水细胞培养及染色体核型分析是安全、可靠的产前诊断方法。
Objective To investigate the application value of amniotic cell culture and karyotype analysis in prenatal diagnosis . Methods 1 016 pregnant women in second trimester were subject to amniocentesis under the guidance of B-type ultrasonic inspec-tion ,and the cell culture and karyotype analysis were performed on the amniotic fluid which had been drawn out .Results Among 1 016 pregnant women ,1 011（99 .5% ） succeeded in the first operation of amniocentesis and cell culture .The detection rate of fetal chromosomal abnormal karyotype was 10 .3% （105/1 016） ,in which 8 .3% （85/1 016） of structural abnormality and 2 .0%（20/1 016） of quantity abnormality .856 cases were received follow-up .Conclusion Amniotic fluid cell culture and karyotype analy-sis is a safe and reliable method for prenatal diagnosis .
出处
《国际检验医学杂志》
CAS
2014年第9期1138-1139,1142,共3页
International Journal of Laboratory Medicine
