摘要
【目的】观察静脉注射盐酸戊乙奎醚（长托宁）对消除麻醉诱导期丙泊酚注射痛的有效性和安全性。【方法】本院40例ASAⅠ～Ⅱ级择期全麻耳鼻喉科手术患者，随机分为长托宁组（W组）和对照组（C组），每组20例。C组患者麻醉诱导前采用生理盐水10mL静脉注射；W组0．01mg/kg长托宁（生理盐水稀释为10mL）静脉注射。20min后静脉注射2mg/kg丙泊酚，30s注射完毕。采用口述分级评分法（VRS）分别评估比较丙泊酚注射时患者的疼痛评分情况。记录患者入手术室（T1）、试验药物（长托宁或者生理盐水）注射后5min（T2）、10min（T3）、15min（T4）、20min（T5）患者的血压和心率变化。【结果】W组患者疼痛评分明显低于C组（0．9±0．7比1．7±0．9，P＝0．04）；注射痛发生率也低于C组，且两组相比较差异有显著性（40％比90％，P＜0．05）。两组间血压和心率的变化比较差异均无显著性（P＞0．05）。【结论】长托宁能有效缓解麻醉诱导期丙泊酚注射痛。
[Objective]To observe the effectiveness and safety of intravenous penehyclidine hydrochloride on eliminating propofol injection pain during anesthesia induction .[Methods]A total of 40 ASA I-Ⅱ pa-tients scheduled for elective operation of otolaryngology under general anesthesia were randomly divided into group W（penehyclidine hydrochloride group） and group C （control group） with 20 patients in each group . Group C was given intravenous normal saline 0 .9% before anesthesia induction ,while group W was given in-travenous penehyclidine hydrochloride 0 .01mg/kg（diluted with 0 .9% normal saline into 10mL） and then intra-venous propofol 20mg/kg after 20min for 30s .Verbal rating scale（VRS） was used to evaluate and compared the propofol injection pain of patients .Blood pressure and heart rate of patients at entering the operation （T1 ） , 5min（T2 ） ,10min（T3 ） ,15min（T4 ） and 20min（T5 ） after the injection of penehyclidine hydrochloride or nor-mal saline were recorded .[Results]The pain score of patients in group W was obviously lower than that in group C（0 .9 ± 0 .7 vs .1 .7 ± 0 .9 ,P =0 .04） .The incidence of injection pain in group W was also lower than that in group C ,and there was significant difference between two groups （40% vs .90% ,P 〈0 .05） ,There was no significant difference in blood pressure and heart rate between two groups （ P 〉 0 .05） .[Conclusion]Penehyclidine hydrochloride can effectively alleviate propofol injection pain during anesthesia induction .
出处
《医学临床研究》
CAS
2014年第4期651-653,共3页
Journal of Clinical Research
基金
中南大学中央高校基本科研业务费专项资金资助（2013zzts346）
