摘要
目的探讨长春瑞滨(NVB)联合顺铂(DDP)的NP方案时辰化疗治疗非小细胞肺癌(NSCLC)的临床疗效和安全性。方法 2007年5月至2010年5月期间收治的140例NSCLC患者,选取接受NP时辰化疗的45例患者作为试验组,在17:00至21:00连续4h静脉滴注NVB,在10:00点至22:00连续12h静脉滴注DDP,在2:00点至5:00点连续3h静脉滴注紫杉醇。同时选取46例接受常规化疗的患者作为对照组,用药方案和用药剂量与试验组相同,均为上午时间用药。观察和比较两组患者临床疗效、生活质量改善情况和不良反应。结果试验组完全缓解率(CR)为11.1%,有效率(RR)为55.6%,临床控制率为88.9%,均显著高于对照组(均P<0.05)。试验组生存时间(MST)为(15.24±2.56)个月,无进展生存时间(PFS)为(8.04±1.57)个月,显著高于对照组(P<0.05)。试验组1年和2年生存率分别为57.8%和48.9%,显著高于对照组(P<0.05);试验组总体健康评分为(87.23±7.44)分,显著高于对照组的(76.45±7.11)分(P<0.05);试验组Ⅱ度以上白细胞下降发生率为28.9%,显著低于对照组的52.2%,差异有统计学意义(P<0.05)。试验组患者Ⅱ度以上恶心呕吐发生率为15.6%,显著低于对照组的41.3%,差异有统计学意义(P<0.05)。试验组Ⅱ度以上血小板下降发生率为4.4%,显著低于对照组10.9%(P<0.05)。结论与常规化疗比较,NP方案时辰化疗可延长NSCLC患者的生存时间,改善患者化疗后生活质量,不良反应耐受性好,安全性高,综合疗效优于常规化疗。
Objective To investigate the clinical efficacy and safety of the Chrono-chemotherapy with vinorelbine and cisplatin （NP） on non-small cell lung cancer （NSCLC）. Methods One hundred and forty cases of NSCLC patients in 2007 May to 2010 May in our hospital were retrospective analyzed and 45 NSCLC cases received NP chemotherapy were selected as the observation groups, who received chrono- chemotherapy at 17：00 to 21：00 for 4 hours of continuous administration of intravenous infusion of vinorel- bine （NVB）, at 10：00 to 22：00 for 12 hours of continuous intravenous infusion of cisplatin （DDP）, and at 2：00 to 5：00 for 3 hours of continuous administration of paclitaxel. At the same time, 46 cases received conventional chemotherapy were selected as the control groups. The drug regimen and dosage of control groups were the same as observation group, and the time of administration was in the morning. The clinical efficacy, quality of life and adverse reaction of the two groups were observed and compared. Results The CR, RR and the clinical control rate of the observation groups were 11.1%, 55.6% and 88.9% respectively, which were higher than those of the control groups （P 〈 0. 05 ）. The MST and PFS of the observation groups were （ 15.24±2. 56） and （8.04 ± 1.57） months respectively, which were significantly longer than those of the control groups （P 〈0. 05）. The one year and two years survival rate were 5% 8% and 48. 9%,respectively, which were significantly higher than those of the control groups （ P 〈 O. 05 ）. The general health score of the observation groups was （ 87.23 ± 7.44） points, significantly higher than that of control group （76.45 ± 7. 11 ） points （ P 〈 0. 05 ）. The cases with white blood cells decreased, nausea and vomi- ting and thrombocytopenia about Ⅱ degree or above in the observation groups were 28.9% , 15.6% and 4.4% , respectively, which were significantly lower than those of the control groups （ P 〈 0.05 ）. Conclusion Compari
出处
《中国肿瘤临床与康复》
2014年第5期559-562,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
癌
非小细胞肺
药物疗法
治疗结果
Carcinoma, non-small cell lung
Drug therapy
Treatment outcome
