摘要
目的观察广西地区慢性肾炎中医证型的分布规律,并探讨其与尿蛋白、肾功能等实验室指标的相关性。方法对140例慢性肾炎患者的一般情况、分期、中医主证和标证型进行统计描述,检测患者的尿蛋白、肾功能(尿素氮(BUN)、血肌酐(SCr)),并分析中医证型与这些实验检查指标的关系。结果 140例慢性肾炎患者本证中,中医证型分布和CKD分期有相关性(P<0.001),Ⅰ期和Ⅱ期与脾肾气虚证相关;Ⅲ期与肝肾阴虚型相关,Ⅳ期与脾肾阳虚证相关。标证中,从Ⅰ期进展至Ⅳ期,外感证、湿浊证和瘀血证均逐渐增多,但湿热证则有减少的趋势。肝肾阴虚证和脾肾气虚证患者的尿蛋白、BUN、SCr水平差异无统计学意义。而与肝肾阴虚证和脾肾气虚证相比较,脾肾阳虚证患者的尿蛋白、BUN、SCr水平明显升高(P均<0.01)。结论广西地区慢性肾炎证型演变规律为脾肾气虚-肝肾阴虚-脾肾阳虚,瘀血证和湿浊是最主要的指标。尿蛋白、BUN、SCr水平与脾肾阳虚证可能存在一定相关性,临床上可能作为辨证论治的客观指标。
Objective It is to observe the evolvement rule of Chinese medical syndrome typing of chronic nephritis inGuangxi area and its correlation with examination indexes such as urine protein and renal function. Methods Statistical de-scriptions of the normal condition, stage, incidental symptom and fundamental symptom of TCM of 140 patients with chronicnephritis were made, and urine protein, renal function （BUN, SCr） were determined to analyze the relationship between TCMsyndromes and examination indexes. Results In the fundamental symptoms of 140 patients with chronic nephritis, the syn-drome types of TCM were correlated with CKD stage（P 〈 0. 001 ）, stage I and 11 were related with spleen-kidney Qi-defi-ciency, stage III was related with liver-kidney Yin-deficiency, stage 1V was related with spleen-kidney Yang-deficiency. In in-cidental symptoms, exogenous syndrome, turbid dampness syndrome and blood stasis syndrome increased gradually, but heatdampness syndrome had a decreasing tendency. There was no significant difference in urine protein, BUN and SCr levels be-tween spleen-kidney Qi-deficiency and liver-kidney Yin-deficiency patients, but the levels increased obviously in spleen-kid-ney Yang-deficiency patients（ P 〈 0.01 ）. Conclusion The evolvement rule of Chinese medical syndrome typing of chronic ne-phritis in Guangxi area is that spleen-kidney Qi-deficiency-liver-kidney Yin-deficiency-spleen-kidney Yang-deficiency, bloodstasis syndrome and damp-turbid are main indexes. The levels of urine protein, BUN and SCr are related with spleen-kidneyYang-deficiency, which can be used as objective indexes for syndrome differentiation and treatment.
出处
《现代中西医结合杂志》
CAS
2014年第16期1715-1717,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
广西中管局中医药科技专项课题资助项目(GZKZ09-26)
关键词
慢性肾炎
尿蛋白
肝肾阴虚
脾肾气虚
脾肾阳虚
chronic nephritis
urine protein
spleen-kidney Qi-deficiency
liver-kidney Yin-deficiency
spleen-kidneyYang-deficiency
