摘要
肠道病毒71型(EV71)是导致婴幼儿手足口病的主要病原体,EV71感染可以导致重症手足口病和严重的神经系统并发症,脑干脑炎、神经源性肺水肿是EV71感染后最严重的并发症,也是导致死亡的主要原因,全身炎症反应综合征被认为与感染者病情危重相关,大量病毒诱导的炎性因子可能是EV71感染的致病机制。静脉给予人免疫球蛋白可以起到调节免疫反应的作用,并改善EV71导致的肺水肿患者的预后。其中白细胞介素6(IL-6)在EV71感染者体内中浓度水平升高,而在动物模型中给予抗IL-6治疗可以缓解症状,改善动物预后。
Enterovirus 71 （EV71） is a major etiological agent of hand ,foot, and mouth disease（HMFD）.EV71 has been associated with severe HFMD and severe neurological complications. Brain stem encephalitiswith pulmonary edema is the most severe complication that can lead to death. The systemic inflammatoryresponses to infection play important roles in the pathogenesis of EVT1 pulmonary edema. It was proposedthat overwhelming virus replication combined with the induction of massive proinflammatory cytokines isresponsible for the pathogenicity of EVT1, administration of intravenous immunoglobulin has been shown tomodulate inflammation,to reduce sympathetic overactivity, and to improve prognosis of patients with EV71pulmonary edema. The EVTI infection leads to the production of sustained high levels of IL-6 in the patients.Administration of anti-IL-6 neutralizing antibodies in animal models after disease symptoms started to mani-fest significantly improved the clinical symptoms and prognosis.
出处
《医学综述》
2014年第8期1440-1442,共3页
Medical Recapitulate
关键词
细胞因子
白细胞介素6
手足口病
Cytokine
Interleukin 6
Hand, foot, and mouth disease
