摘要
目的通过研究湖北地区慢性肾脏疾病（chornic kidney diseases，CKD）3～5期患者腹主动脉钙化的发生情况及影响因素，为CKD中晚期出现血管钙化的患者的提供临床诊疗依据。方法将123例患者按CKD不同分期分为CKD3期组、CKD4期组和CKD5期组，收集所有患者的一般资料，包括性别、年龄、身高、体质量、体质量指数（bodymassindex，BMI）、高血压病史及糖尿病病史；比较各组患者的血肌酐、白蛋白、前白蛋白、总胆固醇（total cholesterol，TC）、三酰甘油（triglyc—eride，TG）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）、空腹血糖、血钙、血磷、甲状旁腺素（parathyroidhor—mone，PTH）及超敏C反应蛋白（high sensitive c-reactive protein，hs-CRP）的水平，并评估腹主动脉钙化的发病率及其相关影响因素。结果CKD3期组血磷、钙磷乘积及PTH水平高于CKD4期组和CKD5期组（P〈0．01，P〈0．05），而血钙水平低于CKD4期组，但无统计学差异（P〉0．05），与CKD5期组比较，有统计学差异（P〈0．05）；CKD5期组血钙与CKD4期组比较有统计学意义（P〈0．05）；其余实验室指标在CKD各期组比较均无统计学意义（P〉0．05）。根据患者有无腹主动脉钙化将其分为腹主动脉钙化组和非钙化组，2组的年龄和hs—CRP相比有统计学意义（P〈0．01，P〈0．05）；以腹主动脉钙化为因变量，将年龄、高血压病史发病率及hs—CRP三项因素进行logistic相关性分析，结果显示年龄与腹主动脉钙化有统计学意义。结论年龄为CKD3～5期患者腹主动脉钙化的独立影响因素，而hs—CRP和高血压发病率也是影响CKD患者腹主动脉钙化的重要因素。
Objective To understand the incidence and the influencing factors of abdominal aortic calcification in patients with advanced chronic kidney disease （CKD） in Hubei area in order to pro- vide the evidence for diagnosis and treatment of abdominal aortic calcification of intermediate and late CKD. Methods 123 cases of CKD from the Nephrology outpatient and inpatient of Hubei Provincial Hospital were divided into three groups according to the CKD stages. The general information [inclu- ding gender, age, height, weight and body mass index （BMI） and history of hypertension and diabetes mellitus] was collected. Serum creatinine, albumin, prealbumin, total cholesterol （TC）, triglyceride （TG） ,high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, fasting blood glucose, serum calcium, serum phosphorus, parathyroid hormone （PTH） and high-sensi- tivity C-reactive protein （hs-CRP） levels were compared among the CDK stages. The morbidity rate of abdominal aortic calcification and its related factors were assessed. Results There were statistically significant difference in serum calcium, serum phosphorus, calcium-phosphorus product and PTH lev- els among stages 3, 4 and 5 of CKD （P〈0. 01）. Serum phosphorus, calcium-phosphorus product and PTH levels at stage 3 of CKD were significantly higher than those at stage 4 and 5 of CKD （P〈0. 01, or P〈0. 05）. Serum calcium at stage 5 of CKD was significantly decreased as compared with that at stage 3 and 4 of CKD （P〈0. 05）. There was significant difference in age and hs-CRP between abdomi- nal aortic calcification group and non-abdominal aortic calcification group （P〈0. 001 or P〈0. 05）. Lo- gistic correlation analysis revealed that abdominal aortic calcification was associated with age. Conclu- sions The result showed age was independently associated with abdominal aortic calcification, and high sensitivity hs-CRP and morbidity rate of hypertension were the important factors for abdominal aort
出处
《临床肾脏病杂志》
2014年第4期204-208,共5页
Journal Of Clinical Nephrology
关键词
慢性肾脏疾病
腹主动脉钙化
高血压
超敏C反应蛋白
Chronic kidney disease
Abdominal aortic calcification
Hypertension
High sensi- tivity C-reactive protein
