摘要
目的了解云南省当地各民族孕妇唐氏综合征高风险状况，探讨孕中期唐氏征筛查检测的临床意义。并提出干预措施，为制定预防出生缺陷措施提供决策依据。方法收集云南省第一人民医院对云南省德宏州人民医院2010年-2013年产检5000例孕15—20^＋6周妊娠妇女进行唐氏征筛查的资料，并对其结果进行分析。结果5000例孕妇中，唐氏综合征筛查高风险115例，占筛查总数的2．3％。唐氏征筛查阳性病例行羊水穿刺术，发现21-三体综合征15例，占筛查病例的0．3％；18-三体综合征18例，占筛查总数的0．36％；神经管缺损高风险13例，占筛查总数的0．26％。结论有效的孕中期产前筛查能够在一定程度上减少新生儿缺陷的发生率。
Objective： To understand the local minority pregnant women with high risk of Down＇ s syndrome, the clinical significance of second trimester Down syndrome screening test. And puts forward the measures for prevention andintervention, to provide basis for decision making of birth defect measure. Methods： The first people＇ s Hospital of Yunnan province were collected in our hospital from 2010-2013 annual inspection on 5000 cases in 15 to 20^＋6 weeks of pregnancy women were down＇ s screening data, and the results of the analysis. Results： In 5000 cases of pregnant women, screening for Down＇ s syndrome 115 cases with high risk, accounting for 2.3% of the total number of screening. Down＇ s screening positive cases underwent amniocentesis, found 15 cases of trisomy 21-syndrome, accounting for screening in 0.3% of cases~ 18 cases of 18-syndrome, accounted for 0.36% of the total number of screening; 13 cases of neural tube defects of high risk, accounting for 0.26% of the total number of screening. Conclusions： Effective second trimester prenatal screening can reduce the incidence of birth defects in a certain extent.
出处
《中国优生与遗传杂志》
2014年第5期61-62,85,共3页
Chinese Journal of Birth Health & Heredity
