摘要
脉络膜新生血管可见于多种眼部疾病,是引起视力损害的重要原因之一.近期多项研究表明,Notch信号在脉络膜新生血管的发生中起着关键性作用.作为相邻细胞间的信号转导通路,Notch信号途径可参与血管形成中的多个步骤,并与多种细胞及多种信号通路发生交互作用.因此,揭示Notch信号在脉络膜新生血管中的作用及其机制,对该类疾病的发生机制和靶向治疗具有重要意义.
Choroidal neovascularization,a prevalent cause of severe visual loss,has been observed in many ocular diseases.Recent studies suggest that the Notch pathway plays a critical role in choroidal neovascularization.As a classic signaling pathway transducting in neighboring cells,Notch pathway is critically involved in several angiogenic steps,and interacted with cells and other signaling pathways.In conclusion,it is of great significance for the mechanisms and therapeutic potential to reveal its roles and mechanisms in choroidal neovascularization.
出处
《国际眼科纵览》
2014年第2期113-118,共6页
International Review of Ophthalmology
基金
国家自然科学基金（81200707）
国家重点基础研究发展计划（2011CB510202）
陕西省社会发展攻关项目（2011K12-46）
