摘要
目的探讨乳腺癌适形放疗后导致放射性肺炎发生的危险因素。方法选择接受适形放疗的乳腺癌患者150例作为研究对象,采用单因素方差分析及多因素Logistic回归分析对包括年龄、是否合并糖尿病、病理类型、临床分期、是否化疗、化疗方案、化疗周期数、是否内分泌治疗、处方剂量以及照射野面积等因素进行分析,筛选与放疗后放射性肺炎发生有关的危险因素。结果乳腺癌实行放疗后放射性肺炎的发生率为14.67%。筛选并确定接受化疗、合并糖尿病、化疗周期≥4、处方剂量≥50 Gy以及照射野面积≥120 cm2为乳腺癌适形放疗后发生放射性肺炎的危险因素。结论接受化疗、合并糖尿病、化疗周期≥4、处方剂量≥50 Gy以及照射野面积≥120 cm2为乳腺癌适形放疗后发生放射性肺炎的危险因素,在制定放疗计划时应考虑与放射性肺炎有关的危险因素。
[ Objective ] To explore the related risk factors for radiation pneumonitis（RP） after treatment of conformal radiotherapy （CRT） in patients with breast cancer. [Methods] 150 patients with breast cancer received CRT were selected in this study. Clinical data including age, complication of diabetes, pathology, clinical staging, chemotherapy, chemotherapy cycle, endocrine therapy, exposure area and prescription dose of radiotherapy were analyzed by on way ANOVA and Logistic regression analysis. [Results] Incidence of RP after CRT was 14.67%. Chemotherapy, complication of diabetes, chemotherapy cycle ≥4, prescription dose ≥50 Gy and exposure area ≥ 120 cm2 were identified as risk factors for RP after CRT in patients with breast cancer. [Conclusions] Chemotherapy, complication of diabetes, chemotherapy cycle 〉14, prescription dose ≥50 Gy and exposure area ≥ 120 cm2 were identified as risk factors for RP after CRT in patients with breast cancer. These factors should be paid attention when developing radiation treatment planin patient with breast cancer.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2014年第7期99-102,共4页
China Journal of Modern Medicine
关键词
乳腺癌
适形放疗
放射性肺炎
危险因素
breast cancer
conformal radiotherapy
radiation pneumonitis
risk factors
