期刊文献+

冠状动脉慢血流现象相关危险因素的分析 被引量:13

Analysis of the clinical risk factors of coronary slow flow phenomenon
下载PDF
导出
摘要 目的初步探讨冠状动脉慢血流现象的危险因素。方法回顾性分析我院2010年7月至2013年1月因疑似冠心病行冠状动脉造影检查。明确冠状动脉无明显病变的患者142例,采用心肌梗死溶栓(TIMI)记帧法记录各支冠状动脉的TIMI帧数,冠状动脉平均TIMI帧数大于27为冠状动脉慢血流,将患者分为冠状动脉慢血流组(CSF组,68例)和对照组(74例)。对两组间各项临床指标的差异进行比较,并采用多元Logistic回归分析对冠状动脉慢血流的危险因素进行回归分析。结果CSF组与对照组患者高密度脂蛋白胆固醇[(1.02±0.28)mmol/L vs.(1.29±0.33)mmol/L]、血同型半胱氨酸水平[(24.46±2.54)mmol/L vs.(11.81±2.80)mmol/L]、体质指数[(25.91±1.72)kg/m2 vs.(22.82±1.53)kg/m2]、吸烟量[(374.24±182.48)支年vs.(198.68±116.53)支年]比较差异均有统计学意义(P〈0.05),多元Logistic回归分析表明体质指数升高(OR=I.38,95%CI:1.0246~1.8278,P=0.031)、大量吸烟(OR=1.0067,95%CI:1.0025.1.0109.P=0.0017)、高同型半胱氨酸血症(OR=I.12,95%CI:1.1023~1.1291,P=0.0014)为冠状动脉慢血流发生的危险因素。结论体质指数升高、高同型半胱氨酸血症和大量吸烟作为冠状动脉慢血流现象的危险因素,可能参与冠状动脉慢血流现象发生的病理生理过程。 Objective To investigate the clinical risk factors of coronary slow flow phenomenon. Methods One hundred and forty-two patients with angiographically proven normal coronary arteries admitted during July 2010 to Jan 2013 were included in this study. Coronary flow rates of all patients were documented by Thrombolysis In Myocardial Infarction frame count (TIMI frame count). Patients whose average TIMI frame count greater than 27 were included in the Coronary Slow Flow Phenomenon group (n=68) and others were included as the control group (n=74). Comparison of cate- gorical and continuous variables between the two groups was performed using chi-square and unpaired t-test respectively. Multivariate analysis evaluating predictors of coronary slow flow phenomenon was performed using logistic regression test. Results Body mass index (BMI), hyperhomocysteinemia (HHcy), smoking and low-lipid lipoprotein level were significantly higher in the coronary slow flow group compared with the control group (P 〈 0.015). High-density lipoproteins was lower in the coronary slow flow group compared with the control group, the difference was statistically significant (P 〈 0.05). After adjusted with other variables by logistic regression test, BMI (OR 1.38, 95%CI:1.02-1.82, P = 0.031), smoking (OR1.0067, 95% CI:1.0025-1.0109, P = 0.0017) and HHcy (OR 1.12, 95%CI:1.0023-1.1291, P = 0.0014) were proven to be the risk factors for slow coronary flow. Conclusion Increasing in BMI, smoking and HHcy may play a role in the pathogenesis of slow coronary flow.
出处 《北京医学》 CAS 2014年第5期347-349,共3页 Beijing Medical Journal
关键词 冠状动脉慢血流现象 体质指数 吸烟 高同型半胱氨酸血症 Coronary slow flow phenomenon Body mass index (BMI) Smoking Hyperhomocysteine (HHcy)
  • 相关文献

参考文献8

  • 1Tambe AA, Demany MA, Zimmerman HA, et al. Angina pectoris and slow flow velocity of dye in coronary arteries a new angio- graphic finding[J]. Am Heart J, 1972, 84:66-71. 被引量:1
  • 2Beltrame JF, Limaye SB, Horowitz JD, et al. The coronary slow phenomenon: a new coronary microvaseular disorder[J]. Cardiolo- gy, 2002, 97:197-202. 被引量:1
  • 3Celebi H, Catakoglu AB, Kurtoglu H, et al. The relation between coronary flow rate, plasma endothelin-1 concentrations, and clini- cal characteristics in patients with normal coronary arteries [J]. Cardiovasc Revasc Med, 2008, 9:144-148. 被引量:1
  • 4Erbay AR, Turhan H, Senen K, et al. Documentation of slow coro- nary flow by the thrombolysis in myocardial infarction frame count in habitual smokersw ith anglo-graphically normal coronary arter- ies[J]. Heart Vessels, 2004, 19:271-274. 被引量:1
  • 5李军,马长生.冠状动脉慢血流现象的研究进展[J].心血管病学进展,2010,31(3):356-359. 被引量:38
  • 6Garcia-Rios A, Delgado-Lista J, Alcala-Diaz JF, et al. Nutraceu- ticals and coronary heart disease [J]. Curr Opin Cardiol, 2013, 28: 475-482. 被引量:1
  • 7吴焱贤,钟建开,陈玉映,陈盈文,黎文生,吴赛珠.急诊介入慢血流的发生及预后与同型半胱氨酸水平的相关性[J].南方医科大学学报,2013,33(3):416-419. 被引量:6
  • 8Yucel H, Ozaydin M, Dogan A, et al. Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow [J]. Scand J Clin Lab In- vest, 2012, 72:495-500. 被引量:1

二级参考文献43

  • 1Tambe AA,Demany MA,Zimmerman HA,et al.Angina pectoris and slow flow velocity of dye in coronary arteries:a new angiographic finding[J].Am Heart J,1972,84:66-71. 被引量:1
  • 2Celebi H,Catakoglu AB,Kurtoglu H,et al.The relation between coronary flow rate,plasma endothelin-1 concentrations,and clinical characteristics in patients with normal coronary arteries[J].Cardiovasc Revasc Med,2008,9:144-148. 被引量:1
  • 3Erbay AR,Turhan H,Senen K,et al.Documentation of slow coronary flow by the thrombolysis in myocardial infarction frame count in habitual smokers with angiographically normal coronary arteries[J].Heart Vessels,2004,19:271-274. 被引量:1
  • 4Yamashita K,Takahiro K,Kamezaki F,et al.Decreased plasma extracellular superoxide dismutase level in patients with vasospastic angina[J].Atherosclerosis,2007,191:147-152. 被引量:1
  • 5Tanriverdi H,Evrengul H,Enli Y,et al.Effect of homocysteine-induced oxidative stress on endothelial function in coronary slow flow[J].Cardiology,2007,107:313-320. 被引量:1
  • 6Fineschi M,Bravi A,Gori T.The "slow coronary flow" phenomenon:evidence of preserved coronary flow reserve despite increased resting microvascular resistances[J].Int J Cardiol,2008,127:358-361. 被引量:1
  • 7Mosseri M,Yarom R,Gotsman MS,et al.Histologic evidence for small vessel coronary artery disease in patients with angina pectoris and patent large coronary arteries[J].Circulation,1986,74:964-972. 被引量:1
  • 8Erdogan D,Caliskan M,Gullu H,et al.Coronary flow reserve is impaired in patients with slow coronary flow[J].Atherosclerosis,2007,191:168-174. 被引量:1
  • 9Beltrame JF,Turner SP,Leslie SL,et al.The angiographic and clinical benefits of mibefradil in the coronary slow flow phenomenon[J].J Am Coll Cardiol,2004,44:57-62. 被引量:1
  • 10Sezgin AT,SigirciA,Barutcu I,et al.Vascular endothelial function in patients with slow coronary flow[J].Coron Artery Dis,2003,14:155-161. 被引量:1

共引文献42

同被引文献132

引证文献13

二级引证文献51

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部