摘要
目的探讨大气PM2.5对哮喘患者炎症因子的影响,寻找用于评价PM2.5污染效应的敏感指标,为阐明PM2.5加重哮喘发生的机制提供参考。方法选择太原市迎泽区社区哮喘患者19名,分别于2012年12月和2013年6月对患者进行7 d的大气PM2.5暴露监测,并于监测最后一天采集血样进行炎症因子检测,比较两阶段哮喘患者的PM2.5暴露差别及体内相关炎症因子[白介素-8(IL-8)、白介素-13(IL-13)、γ干扰素(IFN-γ)]的变化情况。结果哮喘患者冬季室外、室内大气PM2.5暴露日均浓度和个体PM2.5暴露日均浓度均高于夏季;冬季血浆炎症因子IL-13浓度高于夏季,IFN-γ浓度低于夏季,差异均有统计学意义(P<0.05)。哮喘患者个体PM2.5暴露浓度与室外、室内PM2.5暴露浓度呈正相关(r值分别为0.809,0.826,P<0.05),室外PM2.5暴露浓度与室内PM2.5暴露浓度呈正相关(r=0.769,P<0.05)。哮喘患者血浆IL-8浓度与个体PM2.5暴露浓度呈正相关(r=0.498,P<0.05);血浆IL-13与室外PM2.5暴露浓度呈正相关(r=0.579,P<0.05),与IFN-γ浓度呈负相关(r=-0.536,P<0.05)。结论外周血中炎症因子IL-13、IFN-γ可能是大气PM2.5加重哮喘的敏感指标。
Objective To study the impact of PM2.5 on asthma and to search the sensitive indicators for evaluation of PM2.5 pollution effect in order to elucidate the mechanism of PM2.5 worsening the occurrence of asthma. Methods Nineteen patients with asthma were chosen from Yingze district, Taiyuan, and continuous tracking monitoring PM2.5 exposure in two phases （winter and summer）, with seven days each time in December 2012 and June 2013 was conducted. The blood samples on the last day of monitoring were collected and PM2.5 exposure difference and related inflammatory factor changes were determined. Results In winter, outdoor PM2.5 exposure concentration, indoor PM2.5 exposure concentration and individual PM2.5 exposure concentration were significantly higher than those in summer （P〈0.05）, plasma inflammatory cytokines IL-13 concentrations of asthma patients in winter were significantly higher than those in summer, IFN-γ concentration was significantly lower than that in summer （P〈0.05）. Individual PM2.5 exposure concentrations of patients with asthma were positively correlated with outdoor and indoor PM2.5 exposure concentrations （r=0.809, 0.826, P〈0.05）. Indoor PM2.5 exposure concentrations were positively correlated with PM2.5 outdoor exposure concentrations （r=0.769, P〈0.05）. Individual PM2.5 exposure concentrations were positively correlated with IL-8 （r=0.498, P〈0.05）, plasma IL-13 concentration was positively related with outdoor PM2.5 exposure concentration （r=0.579, P〈O.05）, and negatively correlated with IFN-γ level （r=-0.536, P〈0.05）. Conclusion Peripheral blood inflammation factors IL-13 and IFN-γ are regarded as the sensitive indexes for PM2.5 worsening asthma.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2014年第3期229-231,共3页
Journal of Environment and Health
基金
教育部留学回国人员科研启动基金(2013-1792)
山西省回国留学人员科研资助项目(2013-057)
山西省高校优秀青年学术带头人支持项目(晋教科2009-6)
关键词
PM2
5
哮喘
炎症因子
PM2.5
Asthma
Inflammatory factors
