摘要
目的探讨前列地尔注射液微泵给药治疗小儿高原性心脏病(high altitude heart disease,HAHD)的效果和安全性。方法 60例HAHD患儿按照完全随机设计法分为观察组和对照组各30例,两组均给予常规治疗,观察组在此基础上以微泵静脉持续给予前列地尔注射液[5 ng/(kg·h)],连续应用3天,每天12小时。比较两组治疗后右室射血分数(RVEF)、肺动脉收缩压(SPAP)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)等血气指标变化和临床疗效总有效率。结果观察组治疗后RVEF、SPAP、PaO2、PaCO2指标改善均明显优于对照组,临床总有效率高于对照组,差异有统计学意义(P<0.05)。结论常规治疗基础上加用前列地尔注射液治疗小儿HAHD可明显增强疗效,改善心功能,降低肺动脉压力,纠正缺氧状态。
Objective To explore the efficacy and safety of alprostadil micro pump infusion in treatment of children with high altitude heart disease in plateau area .Methods Sixty children with high altitude heart disease were randomly divided into observation and control groups ,30 cases each .The observation group was given general treatments ,as well as alprostadil injection （ Sebu factor ） with micro pump infusion of 5ng/Kg/hour,12 hours a day for 3 consecutive days.The changes in right ventricular ejection fraction （RVEF）, systolic pulmonary artery pressure（SPAP）,arterial blood pressure（PaCO2）,arterial partial pressure of carbon dioxide （PaCO2） and other blood gas indexes as well as total clinical cure rate were compared between the two groups after treatment .Results The indexes of RVEF,SPAP,PaCO2 and PaCO2 in the observation group were better than that in the control group .The total clinical effective rate in the observation group was higher than that in the control group .The difference was statistically significant （ P＆lt;0.05 ） .Conclusion Al-prostadil injection can significantly improve cardiac function ,reduce pulmonary artery pressure and correct hypoxia in treatment of chil-dren with high altitude heart disease .
出处
《实用医院临床杂志》
2014年第3期100-101,共2页
Practical Journal of Clinical Medicine
关键词
前列地尔
儿童
高原性心脏病
肺动脉高压
充血性心力衰竭
Alprostadil
Children
High altitude heart disease
Pulmonary hypertension
Congestive heart failure
